Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
Huazhi Medical Laboratory Co., Ltd., 618 Heping Road, Changsha 410125, P.R. China.
J Phys Chem Lett. 2022 Sep 1;13(34):7939-7946. doi: 10.1021/acs.jpclett.2c02122. Epub 2022 Aug 18.
The regulation of photochemical properties of phototheranostics, especially the absorption, fluorescence, singlet oxygen (O) generation, and photothermal conversion efficiency, is a hot research topic. Here, we designed and synthesized four boron dipyrromethene (BODIPY) derivatives with high absorption coefficients and intense fluorescence in the near-infrared (NIR) region. The substituted electron-donating group significantly improved O generation and fluorescence of BODIPYs, whereas the electron-withdrawing group boosts photothermal conversion. These hydrophobic BODIPYs were further coated with DSPE-PEG-2000 to form water dispersible nanoparticles (NPs). Among these BODIPY NPs, the B-OMe-NPs with methoxyl substituted at the meso-position showed the highest O generation, a photothermal conversion efficiency of 66.5%, and an NIR fluorescence peak at 809 nm. and experiments demonstrated that B-OMe-NPs might be used for NIR fluorescent and photoacoustic imaging-guided photodynamic and photothermal therapy of cancer.
光热诊疗试剂的光化学性质调控，特别是吸收、荧光、单线态氧（O）生成和光热转换效率，是一个热门的研究课题。在这里，我们设计并合成了四种具有高光吸收系数和强近红外（NIR）区域荧光的硼二吡咯亚甲基（BODIPY）衍生物。取代的给电子基团显著提高了 BODIPYs 的 O 生成和荧光，而吸电子基团则促进了光热转换。这些疏水性 BODIPY 进一步用 DSPE-PEG-2000 进行包覆，形成了水分散性纳米颗粒（NPs）。在这些 BODIPY NPs 中，在中位取代甲氧基的 B-OMe-NPs 表现出最高的 O 生成、66.5%的光热转换效率和 809nm 的近红外荧光峰。 和 实验表明，B-OMe-NPs 可能用于近红外荧光和光声成像引导的癌症光动力和光热治疗。
