Priority Research Centre for Healthy Lungs and Immune Health Research Program, Hunter Medical Research Institute and The University of Newcastle, Callaghan, NSW 2308, Australia.
Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia.
Int J Mol Sci. 2022 Dec 23;24(1):252. doi: 10.3390/ijms24010252.
are prominent gut commensals that produce the short-chain fatty acid (SCFA) acetate, and they are often used as probiotics. Connections between the gut and the lung, termed the gut-lung axis, are regulated by the microbiome. The gut-lung axis is increasingly implicated in cigarette smoke-induced diseases, and cigarette smoke exposure has been associated with depletion of species. In this study, we assessed the impact of acetate-producing subsp. (WT) and a mutant strain with an impaired acetate production capacity (MUT) on cigarette smoke-induced inflammation. The mice were treated with WT or MUT subsp. and exposed to cigarette smoke for 8 weeks before assessments of lung inflammation, lung tissue gene expression and cecal SCFAs were performed. Both strains of subsp. reduced lung inflammation, inflammatory cytokine expression and adhesion factor expression and alleviated cigarette smoke-induced depletion in caecum butyrate. Thus, the probiotic administration of subsp. irrespective of its acetate-producing capacity, alleviated cigarette smoke-induced inflammation and the depletion of cecal butyrate levels.
是肠道中突出的共生菌，它们可以产生短链脂肪酸（SCFA）乙酸盐，常被用作益生菌。肠道和肺部之间的联系，被称为肠肺轴，受微生物组的调节。肠肺轴与香烟烟雾引起的疾病的关系越来越密切，并且香烟烟雾暴露与 物种的消耗有关。在这项研究中，我们评估了产生乙酸盐的 亚种（WT）和一种产乙酸能力受损的突变株（MUT）对香烟烟雾诱导的炎症的影响。用 WT 或 MUT 亚种处理小鼠，并在进行肺炎症、肺组织基因表达和盲肠 SCFA 评估之前，让其暴露于香烟烟雾 8 周。两种 亚种菌株都减轻了肺炎症、炎症细胞因子表达和黏附因子表达，并缓解了香烟烟雾诱导的盲肠丁酸盐消耗。因此，无论其产乙酸能力如何， 亚种的益生菌给药都减轻了香烟烟雾诱导的炎症和盲肠丁酸盐水平的消耗。
