The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Department of Geriatric Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Gut Microbes. 2024 Jan-Dec;16(1):2414805. doi: 10.1080/19490976.2024.2414805. Epub 2024 Oct 24.
The current studies have shown that the occurrence and development of chronic obstructive pulmonary disease (COPD) are closely related to the changes in gut health and its microenvironment, and even some gut diseases have significant clinical correlation with COPD. The dysbiosis of gut microbiota observed in COPD patients also suggests a potential bidirectional interaction between the gut and lung. Communication between the gut and lung may occur through circulating inflammatory cells, gut microbial metabolites, and circulating inflammatory mediators, but the mechanism of bidirectional communication between the gut and lung in COPD is still under study. Therefore, more research is still needed in this area. In this review, we summarize recent clinical studies and animal models on the role of the gut-lung axis in the occurrence and development of COPD and its mechanisms, so as to provide ideas for further research in this field. In addition, we also summarized the negative effects of COPD medication on gut microbiota and the gut microbiota risk factors for COPD and proposed the potential prevention and treatment strategies.
目前的研究表明，慢性阻塞性肺疾病（COPD）的发生和发展与肠道健康及其微环境的变化密切相关，甚至一些肠道疾病与 COPD 有显著的临床相关性。在 COPD 患者中观察到的肠道微生物群落失调也提示了肠道和肺部之间存在潜在的双向相互作用。肠道和肺部之间的通讯可能通过循环炎症细胞、肠道微生物代谢物和循环炎症介质发生，但 COPD 中肠道和肺部之间的双向通讯机制仍在研究中。因此，这方面仍需要更多的研究。在这篇综述中，我们总结了关于肠-肺轴在 COPD 发生和发展中的作用及其机制的最新临床研究和动物模型，为该领域的进一步研究提供思路。此外，我们还总结了 COPD 药物对肠道微生物群的负面影响以及 COPD 的肠道微生物群危险因素，并提出了潜在的预防和治疗策略。
