Department of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wólczańska St., 90-924 Lódź, Poland.
Molecules. 2022 Dec 26;28(1):205. doi: 10.3390/molecules28010205.
Nanoparticles are presently considered the efficient carriers of medicals, cosmetics, and pharmaceuticals in the human organism. There is a lot of research carried out on the delivery of these materials in a non-invasive way. Such a method is very safe in times of global illnesses and pandemics. The most frequently investigated route is the approach to delivering nano-media through the skin as the result of diffusion processes. The stratum corneum, the outermost layer of skin, is the most resistive barrier to such a form of penetration. In this work, a new model is proposed to predict nanoparticles' transport through this layer. It introduces the concept of the three-dimensional model of the stratum corneum, which allows to define the skin surface area from which diffusion occurs. This structure was replaced by the single capillary, resulting from theoretical considerations. Modeling of the diffusion process of nanoparticles as the result of Brownian motion in such a capillary was performed numerically using COMSOL Multiphysics package programs. Further, using the dimensions of such a capillary, a new model of diffusion was developed in which the parameters allow to determine the effective diffusion coefficient as a function of nanoparticle size and the viscosity of a liquid. As a result, the proposed models provide a new and efficient approach to the determination of the nano-molecules' transport phenomena through the skin layer.
纳米粒子目前被认为是医学、化妆品和药物在人体中有效载体。目前有大量关于以非侵入性方式输送这些材料的研究。在全球疾病和大流行时期，这种方法非常安全。最常研究的途径是通过皮肤将纳米介质递送至扩散过程的结果。皮肤的最外层角质层是这种渗透形式的最具抵抗力的屏障。在这项工作中，提出了一种新的模型来预测纳米粒子通过该层的传输。它引入了角质层的三维模型的概念，该模型允许从发生扩散的皮肤表面定义面积。该结构通过理论考虑被单个毛细管所取代。使用 COMSOL Multiphysics 程序包对纳米粒子在这种毛细管中布朗运动的扩散过程进行了数值建模。此外，使用这种毛细管的尺寸，开发了一种新的扩散模型，其中参数允许确定有效扩散系数作为纳米颗粒尺寸和液体粘度的函数。因此，所提出的模型为通过皮肤层确定纳米分子传输现象提供了一种新的有效方法。
