Department of Chemical Engineering, Faculty of Process and Environmental Engineering, Lodz University of Technology, 213 Wolczanska St., 90-924 Lodz, Poland.
Department of Refrigeration Technology and Technique in Lodz, Institute of Agriculture and Food Biotechnology, 84 Al. Marszałka J. Piłsudskiego, 92-202 Lodz, Poland.
Int J Mol Sci. 2022 Jun 8;23(12):6419. doi: 10.3390/ijms23126419.
The non-invasive introduction of active substances into the human body is a top challenge for researchers in medicine, pharmacology, and cosmetology. Development of nanotechnology and possibilities of creating more and more complex drug carriers on a nanoscale give a more realistic prospect of meeting this challenge. However, in the absence of sufficient knowledge of the mechanisms of such systems' transport through the human skin structure, it is necessary to look deeper into these issues. There are several models describing nanoparticles transport through the skin, but they are mainly based on diffusion process analysis. In this work, a model was proposed to predict nanoparticles transport through the skin, based on the combined diffusion and adsorption concept. This approach was based on experimental studies of silver and copper nanoparticles' diffusion process through different filtration membrane layers. Dependence of the degree of adsorption on the surface parameter was described using modified Langmuir equation. Then, these considerations were related to the structure of the stratum corneum, which made it possible to predict the changes in the mass of penetrating nanoparticles as a function of transport path length. A discussion of the presented model, depending on such parameters as nanoparticle size, skin cell thickness, or viscosity of the "intercellular cement", was also performed.
将活性物质无创地引入人体是医学、药理学和化妆品领域研究人员面临的一项重大挑战。纳米技术的发展以及在纳米尺度上制造越来越复杂的药物载体的可能性，为应对这一挑战提供了更现实的前景。然而，由于对这些系统通过人体皮肤结构的传输机制缺乏足够的了解，有必要更深入地研究这些问题。有几种模型描述了纳米颗粒通过皮肤的传输，但它们主要基于对扩散过程的分析。在这项工作中，提出了一种基于扩散和吸附综合概念的预测纳米颗粒通过皮肤传输的模型。该方法基于银和铜纳米颗粒通过不同过滤膜层扩散过程的实验研究。使用改进的 Langmuir 方程描述了吸附程度对表面参数的依赖性。然后，将这些考虑因素与角质层的结构联系起来，这使得预测穿透纳米颗粒的质量随传输路径长度的变化成为可能。还根据纳米颗粒尺寸、皮肤细胞厚度或“细胞间水泥”的粘度等参数对所提出的模型进行了讨论。
