Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Center for Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland.
ACS Synth Biol. 2022 Jan 21;11(1):26-38. doi: 10.1021/acssynbio.1c00547. Epub 2021 Dec 30.
In recent years, significant progress has been observed in the field of skin bioprinting, which has a huge potential to revolutionize the way of treatment in injury and surgery. Furthermore, it may be considered as an appropriate platform to perform the assessment and screening of cosmetic and pharmaceutical formulations. Therefore, the objective of this paper was to review the latest advances in 3D bioprinting dedicated to skin applications. In order to explain the boundaries of this technology, the architecture and functions of the native skin were briefly described. The principles of bioprinting methods were outlined along with a detailed description of key elements that are required to fabricate the skin equivalents. Next, the overview of recent progress in 3D bioprinting studies was presented. The article also highlighted the potential applications of bioengineered skin substituents in various fields including regenerative medicine, modeling of diseases, and cosmetics/drugs testing. The advantages, limitations, and future directions of this technology were also discussed.
近年来，皮肤生物打印领域取得了重大进展，有望彻底改变创伤和手术的治疗方式。此外，它也可以被视为评估和筛选化妆品和药物制剂的合适平台。因此，本文旨在综述 3D 生物打印在皮肤应用方面的最新进展。为了说明该技术的局限性，本文简要描述了天然皮肤的结构和功能。概述了生物打印方法的原理，并详细介绍了制造皮肤等效物所需的关键要素。接着，介绍了 3D 生物打印研究的最新进展。文章还强调了生物工程皮肤替代物在再生医学、疾病建模以及化妆品/药物测试等各个领域的潜在应用。还讨论了该技术的优点、局限性和未来发展方向。
