School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Department of Neurology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.
Molecules. 2023 Jan 3;28(1):402. doi: 10.3390/molecules28010402.
A novel near-infrared (NIR) fluorescent probe () was designed and synthesized for the detection of hypochlorite anion (ClO) using a diaminomaleonitrile group as the recognition site. had large Stokes shift (237 nm) and showed an excellent NIR fluorescence response to ClO with the color change under the visible light. It showed a low detection limit (24.7 nM), high selectivity, and rapid detection (within 2 min) for ClO. The new detection mechanism of on ClO was confirmed by H NMR, MS spectrum, and the density functional theory (DFT) calculations. In addition, the probe was successfully used to detect ClO in HeLa cells.
一种新型的近红外（NIR）荧光探针（）被设计和合成，用于检测次氯酸根阴离子（ClO），其识别位点为二氨基马来腈基团。 具有较大的斯托克斯位移（237nm），对 ClO 表现出优异的近红外荧光响应，在可见光下发生颜色变化。它对 ClO 具有低检测限（24.7 nM）、高选择性和快速检测（在 2 分钟内）。通过 1 H NMR、MS 谱和密度泛函理论（DFT）计算，证实了探针对 ClO 的新检测机制。此外，该探针还成功地用于检测 HeLa 细胞中的 ClO。
