Mitochondria and lysosome-targetable fluorescent probes for hydrogen peroxide.

Hydrogen peroxide (HO), as a key member of the reactive oxygen species (ROS), has a certain regulatory effect on many physiological processes, such as cell proliferation, differentiation and migration. However, abnormal production of HO can cause diseases including cancer, Alzheimer's disease, cardiovascular disease, and so on. Therefore, it is important to detect changes in HO at the subcellular level. In recent years, many fluorescent probes for HO have been developed and used in living cells. In this review, we introduce some typical fluorescent probes for HO with mitochondrial and lysosomal targeting. This review contains targeting strategies, detection mechanisms, optical characteristics and cell imaging of these probes.