Bauman V, Pumpen P, Dishler A, Gren E J
J Virol. 1978 Dec;28(3):717-24. doi: 10.1128/JVI.28.3.717-724.1978.
Replication of RNA bacteriophages in the presence of rifamycin was studied in different Escherichia coli strains that vary in RNase content but are not isogenic: AB259 RNase+, Q13 RNase I- PNPase-, AB105 RNase I- RNase III-. It was found that rifamycin did not affect characteristics of phage replication such as the general pattern of viral RNA synthesis and intracellular development of the phage. These characteristics are strain specific and independent of the cell growth rate, which defines only phage release. The inhibition of cell division by rifamycin interfered with the release of the phage and thus produced an apparent effect of rifamycin on phage replication.
在不同核糖核酸酶含量但非同源的大肠杆菌菌株中研究了RNA噬菌体在利福平存在下的复制情况：AB259（核糖核酸酶阳性）、Q13（核糖核酸酶I阴性，多聚核苷酸磷酸化酶阴性）、AB105（核糖核酸酶I阴性，核糖核酸酶III阴性）。结果发现，利福平不影响噬菌体复制的特征，如病毒RNA合成的总体模式和噬菌体在细胞内的发育。这些特征具有菌株特异性，且与细胞生长速率无关，细胞生长速率仅决定噬菌体的释放。利福平对细胞分裂的抑制干扰了噬菌体的释放，因此对噬菌体复制产生了明显的利福平效应。
