Tan Monique, He Feng, Morris Joan K, MacGregor Graham
Wolfson Institute of Population Health, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
St George's University of London, London, UK.
BMJ Nutr Prev Health. 2022 Aug 16;5(2):164-170. doi: 10.1136/bmjnph-2021-000408. eCollection 2022 Dec.
In China, salt intake is among the highest in the world (~11 g/day) and cardiovascular disease (CVD) accounts for 40% of deaths. We estimated the potential impact of reducing salt intake on CVD events in China, via systolic blood pressure (SBP).
To develop our model, we extracted the effect of salt reduction on SBP from a meta-regression of randomised trials and a population study, and that of SBP on CVD risk from pooled cohort studies.
Reducing population salt intake in China by 1 g/day could lower the risk for ischaemic heart disease by about 4% (95% uncertainty interval 1.8%-7.7%) and the risk for stroke by about 6% (2.4%-9.3%). Should this reduced salt level be sustained until 2030,~9 million (M) (7M-10.8M) CVD events could be prevented, of which ~4M (3.1M-4.9M) would have been fatal. Greater and gradual salt intake reductions, to achieve WHO's target of 30% reduction by 2025 or the Chinese government's target of ≤5 g/day by 2030, could prevent ~1.5 or 2 times more CVD events and deaths, respectively. Should the prolonged effect of salt reduction over several years be accounted for, all estimates of CVD events and deaths prevented would be 25% greater on average.
Bringing down the high salt intake levels in China could result in large reductions in CVD. An easily achievable reduction of 1 g/day could prevent ~9M CVD events by 2030. Urgent action must be taken to reduce salt intake in China.
在中国,盐摄入量位居世界前列(约11克/天),心血管疾病(CVD)导致的死亡占总死亡人数的40%。我们通过收缩压(SBP)评估了减少盐摄入量对中国心血管疾病事件的潜在影响。
为建立我们的模型,我们从随机试验的meta回归和一项人群研究中提取了盐减少对收缩压的影响,以及从汇总队列研究中提取了收缩压对心血管疾病风险的影响。
中国人群盐摄入量每天减少1克可使缺血性心脏病风险降低约4%(95%不确定区间1.8%-7.7%),中风风险降低约6%(2.4%-9.3%)。如果将这种降低后的盐摄入量水平持续到2030年,大约900万(700万-1080万)心血管疾病事件可得到预防,其中约400万(310万-490万)可能是致命的。更大幅度且逐步减少盐摄入量,以实现世界卫生组织到2025年减少30%的目标或中国政府到2030年≤5克/天的目标,分别可预防多1.5倍或2倍的心血管疾病事件和死亡。如果考虑盐减少在数年内的长期影响,所有预防的心血管疾病事件和死亡的估计数平均将增加25%。
降低中国高盐摄入量可大幅减少心血管疾病。每天轻松实现减少1克盐摄入量到2030年可预防约900万心血管疾病事件。中国必须立即采取行动减少盐摄入量。