Zhang Kunli, Huang Qiuyan, Peng Laru, Lin Sen, Liu Jie, Zhang Jianfeng, Li Chunling, Zhai Shaolun, Xu Zhihong, Wang Sutian
Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangdong Provincial Key Laboratory of Livestock Disease Prevention Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, China.
State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Front Cell Dev Biol. 2022 Dec 21;10:1007559. doi: 10.3389/fcell.2022.1007559. eCollection 2022.
Organ transplantation is the main treatment for end-stage organ failure, which has rescued tens of thousands of lives. Immune rejection is the main factor affecting the survival of transplanted organs. How to suppress immune rejection is an important goal of transplantation research. A graft first triggers innate immune responses, leading to graft inflammation, tissue injury and cell death, followed by adaptive immune activation. At present, the importance of innate immunity in graft rejection is poorly understood. Autophagy, an evolutionarily conserved intracellular degradation system, is proven to be involved in regulating innate immune response following graft transplants. Moreover, there is evidence indicating that autophagy can regulate graft dysfunction. Although the specific mechanism by which autophagy affects graft rejection remains unclear, autophagy is involved in innate immune signal transduction, inflammatory response, and various forms of cell death after organ transplantation. This review summarizes how autophagy regulates these processes and proposes potential targets for alleviating immune rejection.
器官移植是终末期器官衰竭的主要治疗方法，已挽救了数万人的生命。免疫排斥是影响移植器官存活的主要因素。如何抑制免疫排斥是移植研究的重要目标。移植器官首先触发固有免疫反应，导致移植器官炎症、组织损伤和细胞死亡，随后是适应性免疫激活。目前，人们对固有免疫在移植排斥中的重要性了解甚少。自噬是一种进化上保守的细胞内降解系统，已被证明参与调节移植后的固有免疫反应。此外，有证据表明自噬可调节移植器官功能障碍。尽管自噬影响移植排斥的具体机制尚不清楚，但自噬参与器官移植后的固有免疫信号转导、炎症反应和各种形式的细胞死亡。本文综述了自噬如何调节这些过程，并提出了减轻免疫排斥的潜在靶点。
