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超声心动图方案：一种用于小鼠中不常用参数的工具。

Echocardiography protocol: A tool for infrequently used parameters in mice.

作者信息

Todd Emily Ann, Williams Monique, Kamiar Ali, Rasmussen Monica Anne, Shehadeh Lina A

机构信息

Department of Medical Education, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.

Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.

出版信息

Front Cardiovasc Med. 2022 Dec 21;9:1038385. doi: 10.3389/fcvm.2022.1038385. eCollection 2022.

DOI:10.3389/fcvm.2022.1038385
PMID:36620641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9810757/
Abstract

Echocardiography is frequently used to evaluate cardiac function in rodent models of cardiovascular disease. Whereas methods to acquire the commonly used echocardiography parameters are well-described in published protocols or manuals, many important parameters are ill-defined and often open to subjective interpretation. Such lack of uniformity has engendered conflicting interpretations of the same parameters in published literature. In particular, parameters such as mitral regurgitation, mitral stenosis, pulmonary regurgitation, and aortic regurgitation that are required to define more esoteric etiologies in rarer mouse models often remain equivocal. The aim of this methods paper is to provide a practical guide to the acquisition and interpretation of infrequently used echocardiography parameters and set a framework for comprehensive analyses of right ventricle (RV), pulmonary artery (PA) pulmonary valve (PV), left atrium (LA), mitral valve (MV), and aortic valve (AoV) structure and function.

摘要

超声心动图常用于评估心血管疾病啮齿动物模型的心脏功能。虽然获取常用超声心动图参数的方法在已发表的方案或手册中有详细描述，但许多重要参数定义不明确，且往往容易受到主观解释的影响。这种缺乏一致性的情况导致在已发表的文献中对相同参数存在相互矛盾的解释。特别是在较罕见的小鼠模型中，用于定义更罕见病因所需的参数，如二尖瓣反流、二尖瓣狭窄、肺动脉反流和主动脉反流，往往仍不明确。本方法论文的目的是为获取和解释不常用的超声心动图参数提供实用指南，并为全面分析右心室（RV）、肺动脉（PA）、肺动脉瓣（PV）、左心房（LA）、二尖瓣（MV）和主动脉瓣（AoV）的结构和功能建立一个框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/02f3057178c2/fcvm-09-1038385-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/7a63802d95b8/fcvm-09-1038385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/cfa218401e9e/fcvm-09-1038385-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/db7b47403d38/fcvm-09-1038385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/c483e94c5e39/fcvm-09-1038385-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/78352ef042ba/fcvm-09-1038385-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/70c6c33d0e15/fcvm-09-1038385-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/8802d63bac03/fcvm-09-1038385-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/5d4b162d6109/fcvm-09-1038385-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/e2a364d4cfcb/fcvm-09-1038385-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/4032456e5549/fcvm-09-1038385-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/f8a0b7cb8c14/fcvm-09-1038385-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/8827761b29fb/fcvm-09-1038385-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/02f3057178c2/fcvm-09-1038385-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/7a63802d95b8/fcvm-09-1038385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/cfa218401e9e/fcvm-09-1038385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/19526fc70618/fcvm-09-1038385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/db7b47403d38/fcvm-09-1038385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/c483e94c5e39/fcvm-09-1038385-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/78352ef042ba/fcvm-09-1038385-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/70c6c33d0e15/fcvm-09-1038385-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/8802d63bac03/fcvm-09-1038385-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/5d4b162d6109/fcvm-09-1038385-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/e2a364d4cfcb/fcvm-09-1038385-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/4032456e5549/fcvm-09-1038385-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/f8a0b7cb8c14/fcvm-09-1038385-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/8827761b29fb/fcvm-09-1038385-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af1/9810757/02f3057178c2/fcvm-09-1038385-g014.jpg

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