Houston Methodist DeBakey Heart & Vascular Center, 6550 Fannin Street, Houston, TX 77030, USA.
Houston Methodist DeBakey Heart & Vascular Center, 6550 Fannin Street, Houston, TX 77030, USA.
Cardiol Clin. 2020 May;38(2):149-160. doi: 10.1016/j.ccl.2020.01.009. Epub 2020 Mar 5.
Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.
右侧心力衰竭（RHF）是由于右心室收缩力受损引起的，其原因包括压力、容量过载或内在心肌收缩功能障碍。亚临床右心室（RV）功能障碍或显性 RHF 的发展是一个负面的预后指标。最近的研究重点是 RV 特异性炎症生长因子和心肌纤维化的介质，以阐明导致 RHF 的机制，并可能指导新型治疗药物的开发。本文重点介绍了 RV 在结构、力学和功能方面的明显变化，以及涉及急性和慢性 RHF 病理生理学的分子和炎症介质。
