Key Laboratory of Neuro-regeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuro-regeneration, Nantong University, 226001 Nantong, Jiangsu, PR China.
Hand Surgery Research Center, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, PR China.
J Control Release. 2023 Feb;354:337-353. doi: 10.1016/j.jconrel.2023.01.002. Epub 2023 Jan 16.
Poly(beta-amino esters, PBAEs) are a promising class of cationic polymers synthesized from diacrylates and amines via Michael addition. Recently, PBAEs have been widely developed for drug delivery, immunotherapy, gene therapy, antibacterial, tissue engineering and other applications due to their convenient synthesis, good bio-compatibility and degradation properties. Herein, we mainly summarize the recent progress in the PBAEs synthesis and their applications. The amine groups of PBAEs could be protonated in low pH environment, exhibiting proton sponge and pH-sensitive abilities. Furthermore, the positive PBAEs can interact with negative genes via electrostatic interactions for efficient delivery of nucleic acids. Moreover, positive PBAEs could also directly kill bacteria by disrupting their membranes at high doses. Finally, PBAEs can augment the immune responses, and improve the bioactivity of hydrogels in tissue engineering.
聚（β-氨基酯）是一类有前途的阳离子聚合物，通过迈克尔加成由二丙烯酸酯和胺合成。最近，由于其合成方便、良好的生物相容性和降解性能，PBAEs 已被广泛开发用于药物输送、免疫治疗、基因治疗、抗菌、组织工程等应用。在此，我们主要总结了 PBAEs 的合成及其应用的最新进展。在低 pH 环境下，PBAEs 的氨基可被质子化，表现出质子海绵和 pH 敏感能力。此外，正 PBAEs 可以通过静电相互作用与负基因相互作用，有效地输送核酸。此外，在高剂量下，正 PBAEs 还可以通过破坏细菌的膜直接杀死细菌。最后，PBAEs 可以增强免疫反应，并提高组织工程中水凝胶的生物活性。
