State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Adv Healthc Mater. 2019 Jan;8(2):e1801359. doi: 10.1002/adhm.201801359. Epub 2018 Dec 14.
Poly(β-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). This progress report discusses the recent developments in design, synthesis, formulations, and applications of PBAEs in biomedical fields and provides a perspective view for the future of the PBAEs.
聚（β-氨基酯）（简称 PBAE 或 PAE）是由丙烯酰胺和胺通过迈克尔加成反应合成的聚合物，具有叔胺和酯固有的特性，如 pH 响应性和生物降解性。单体的多功能性为聚合物提供了具有各种物理化学和机械性能的库。当单独使用或与其他材料一起使用时，PBAE 可以制成不同的制剂，以满足药物输送（例如基因、抗癌药物和抗菌药物输送）和天然复杂模拟（纳米伴侣）的各种要求。本进展报告讨论了 PBAE 在生物医学领域的设计、合成、制剂和应用的最新进展，并对 PBAE 的未来提供了展望。
