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猫营养性继发性甲状旁腺功能亢进症,采用免疫酶法测定猫完整甲状旁腺激素支持诊断。

Nutritional secondary hyperparathyroidism in a kitten, supported by immunoenzymatic measurement of feline intact parathyroid hormone.

机构信息

Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.

出版信息

J Vet Diagn Invest. 2023 Mar;35(2):163-167. doi: 10.1177/10406387221143463. Epub 2023 Jan 10.

DOI:10.1177/10406387221143463
PMID:36625404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9999400/
Abstract

A 6-mo-old, intact male, domestic shorthair cat was referred with a history of poor growth, reluctance to move, and deformation of the nasal profile. The kitten had been fed a diet composed almost exclusively of a complementary pet food and tuna, which was similar to an all-meat diet. We detected osteopenia and hypocalcemia associated with severe parathyroid hormone (PTH) and calcitriol increases; we measured PTH concentrations with an immunoenzymatic method that has been validated in cats. Dietary correction, consisting of a complete and balanced wet pet food formulated for growth, resulted in normalization of calcium and PTH concentrations within 2 mo.

摘要

一只 6 月龄、未去势的雄性、家养短毛猫因生长不良、不愿活动和鼻侧轮廓变形而被转介。这只小猫的饮食几乎完全由一种补充宠物食品和金枪鱼组成,类似于全肉饮食。我们检测到与严重甲状旁腺激素(PTH)和 1,25-二羟维生素 D3 增加相关的骨质疏松症和低钙血症;我们使用已在猫中验证过的免疫酶方法测量了 PTH 浓度。通过饮食纠正,即食用专为生长配制的完整均衡的湿宠物食品,2 个月内钙和 PTH 浓度恢复正常。

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本文引用的文献

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Analytical Validation of a New Immunoenzymatic Method for the Measurement of Feline Parathyroid Hormone in Cats with Chronic Kidney Disease.一种用于测量慢性肾病猫体内猫甲状旁腺激素的新型免疫酶法的分析验证
Animals (Basel). 2021 Oct 29;11(11):3100. doi: 10.3390/ani11113100.
2
Analytical and Clinical Validation of a New Immunoenzymatic Method for the Measurement of Canine Parathyroid Hormone.一种用于测量犬甲状旁腺激素的新型免疫酶法的分析与临床验证
Animals (Basel). 2020 Dec 17;10(12):2411. doi: 10.3390/ani10122411.
3
Clinical Guidelines and PTH Measurement: Does Assay Generation Matter?临床指南和甲状旁腺激素(PTH)测定:检测方法的建立是否重要?
Endocr Rev. 2019 Dec 1;40(6):1468-1480. doi: 10.1210/er.2018-00220.
4
Parathyroid Hormone Fragments: New Targets for the Diagnosis and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder.甲状旁腺激素片段:慢性肾脏病-矿物质和骨异常诊断和治疗的新靶点。
Biomed Res Int. 2018 Nov 29;2018:9619253. doi: 10.1155/2018/9619253. eCollection 2018.
5
Metabolic bone disease and central retinal degeneration in a kitten due to nutritional inadequacy of an all-meat raw diet.一只小猫因全肉生食饮食营养不足导致代谢性骨病和视网膜中央变性。
JFMS Open Rep. 2015 Jun 1;1(1):2055116915579682. doi: 10.1177/2055116915579682. eCollection 2015 Jan-Jun.
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Feline hyperparathyroidism: pathophysiology, diagnosis and treatment of primary and secondary disease.猫甲状旁腺功能亢进:原发性和继发性疾病的病理生理学、诊断与治疗
J Feline Med Surg. 2015 May;17(5):427-39. doi: 10.1177/1098612X15581134.
7
Parathyroid hormone-related protein-induced hypercalcemia due to osteosarcoma in a cat.猫骨肉瘤所致甲状旁腺激素相关蛋白诱导的高钙血症
Vet Clin Pathol. 2015 Mar;44(1):141-4. doi: 10.1111/vcp.12224. Epub 2015 Jan 23.
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Parathyroid hormone concentration in geriatric cats with various degrees of renal function.不同肾功能程度老年猫的甲状旁腺激素浓度
J Am Vet Med Assoc. 2012 Nov 15;241(10):1326-35. doi: 10.2460/javma.241.10.1326.
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Calcium and phosphate homeostasis in hyperthyroid cats: associations with development of azotaemia and survival time.甲状腺功能亢进猫的钙和磷稳态:与氮血症发展及生存时间的关联
J Small Anim Pract. 2012 Oct;53(10):561-71. doi: 10.1111/j.1748-5827.2012.01253.x. Epub 2012 Aug 3.
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Domest Anim Endocrinol. 2012 May;42(4):256-64. doi: 10.1016/j.domaniend.2012.01.003. Epub 2012 Feb 8.