Department of Pathology, Stanford University School of Medicine, Stanford, USA.
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, USA.
Head Neck Pathol. 2024 May 13;18(1):43. doi: 10.1007/s12105-024-01648-z.
Cribriform adenocarcinoma of the salivary gland (CASG) is an entity that is currently classified under polymorphous adenocarcinoma (PAC), cribriform subtype per the 2022 WHO classification of head and neck tumours. There is debate about whether CASG should be considered a separate diagnostic entity, as CASG differs from conventional PAC in anatomic site, clinical behaviors, and molecular patterns. Herein we describe a challenging and unique case which shares histologic and behavioral features between CASG and conventional PAC with a YLPM1::PRKD1 rearrangement not previously reported in the literature.
涎腺筛状腺癌（CASG）是一种目前被归类为多形性腺癌（PAC）、筛状亚型的实体，根据 2022 年世界卫生组织头颈部肿瘤分类。关于 CASG 是否应被视为一个独立的诊断实体存在争议，因为 CASG 在解剖部位、临床行为和分子模式上与传统的 PAC 不同。在此，我们描述了一个具有挑战性和独特性的病例，该病例在组织学和行为特征上同时具有 CASG 和传统 PAC 的特征，并伴有 YLPM1::PRKD1 重排，这在文献中尚未报道过。
