通过不对称烯胺催化实现多功能手性硅硅环的高对映选择性构建。
Highly Enantioselective Construction of Multifunctional Silicon-Stereogenic Silacycles by Asymmetric Enamine Catalysis.
机构信息
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, Shanghai, 200062, China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, 571158, China.
出版信息
Angew Chem Int Ed Engl. 2023 Feb 20;62(9):e202217724. doi: 10.1002/anie.202217724. Epub 2023 Jan 24.
We report the first highly enantioselective construction of silicon-stereocenters by asymmetric enamine catalysis. An unprecedented desymmetric intramolecular aldolization of prochiral siladials was thus developed for the facile access of multifunctional silicon-stereogenic silacycles in high to excellent enantioselectivity. With an enal moiety, these adducts could be readily elaborated for the diverse synthesis of silicon-stereogenic compounds, and for late-stage modification.
我们报告了首例通过不对称烯胺催化实现硅立体中心高对映选择性构建的方法。因此，开发了一种前所未有的前手性硅亚胺的不对称去对称分子内Aldol 反应，以高对映选择性轻松获得多功能硅立体手性硅杂环。对于具有烯醛部分的这些加合物，可以很容易地进行进一步的合成以获得各种硅立体手性化合物，并进行后期修饰。
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