Ronan S G, Eng A M, Briele H A, Shioura N N, Das Gupta T K
Department of Pathology, University of Illinois at Chicago 60612.
Arch Dermatol. 1987 Oct;123(10):1326-30.
The significance of partial regression in thin malignant melanomas (0.76 mm or less) of the skin was evaluated to determine if the regression was associated with the later development of metastases in patients who previously were considered to have a favorable prognosis. Of 575 patients with primary cutaneous melanoma treated and followed up by the Division of Surgical Oncology at the University of Illinois, Chicago, we found that 103 (18%) had tumors that measured less than 0.76 mm. Of these, 30 (29%) showed histologic evidence of partial regression. In six (20%) of the 30 patients, visceral metastases developed and the patients died. All six had more than 77% regression of their primary tumors. Of the remaining 24 patients, only one had regression greater than 77% and she is still alive three years after diagnosis. Most of these 24 (83%) patients had regression of less than 50% (mean, 29.9%). No metastasis occurred in the 73 patients who had thin melanomas without histologic evidence of regression. It is apparent from this study that patients with thin melanomas who show partial regression cannot be included in the "low-risk" group if the extent of regression is 75% to 80% or more.
对皮肤薄恶性黑色素瘤（厚度为0.76毫米或更薄）中部分消退的意义进行了评估，以确定这种消退是否与先前被认为预后良好的患者发生转移的后期发展有关。在伊利诺伊大学芝加哥分校外科肿瘤学部门治疗并随访的575例原发性皮肤黑色素瘤患者中，我们发现103例（18%）肿瘤厚度小于0.76毫米。其中，30例（29%）有部分消退的组织学证据。在这30例患者中的6例（20%）发生了内脏转移并死亡。所有6例患者原发肿瘤的消退率均超过77%。在其余24例患者中，只有1例消退率超过77%，她在诊断后三年仍然存活。这24例患者中的大多数（83%）消退率小于50%（平均为29.9%）。在73例无消退组织学证据的薄黑色素瘤患者中未发生转移。从这项研究可以明显看出，如果消退程度达到75%至80%或更高，表现出部分消退的薄黑色素瘤患者不能被纳入“低风险”组。
