布地奈德与丙酸倍氯米松治疗哮喘的比较。
Comparison of budesonide and beclomethasone dipropionate for treatment of asthma.
作者信息
Springer C, Avital A, Maayan C, Rosler A, Godfrey S
机构信息
Department of Paediatrics, Hadassah University Hospital, Jerusalem, Israel.
出版信息
Arch Dis Child. 1987 Aug;62(8):815-9. doi: 10.1136/adc.62.8.815.
Abstract
Beclomethasone dipropionate (BDP) and budesonide (BUD) were each given in a dose of 200 micrograms twice daily by metered dose inhaler to 10 asthmatic children already dependent on treatment with steroids. In a double blind randomised crossover study each course lasted one month. No clinically important differences were found between the two treatments when symptom scores, symptom free days, additional use of salbutamol, and results of lung function tests were considered. Metyrapone mildly reduced the plasma concentration of 11-deoxycortisol in two patients during treatment with budesonide, and in four during treatment with beclomethasone. It is concluded that although they are usually safe, both drugs may cause mild adrenal suppression when given in a dose of 200 micrograms twice daily.
摘要
对10名已依赖类固醇治疗的哮喘儿童，使用定量吸入器，每天两次，每次给予200微克的二丙酸倍氯米松（BDP）和布地奈德（BUD）。在一项双盲随机交叉研究中，每个疗程持续1个月。当考虑症状评分、无症状天数、沙丁胺醇的额外使用情况以及肺功能测试结果时，两种治疗方法之间未发现具有临床意义的差异。在使用布地奈德治疗期间，美替拉酮使2例患者的11 - 脱氧皮质醇血浆浓度轻度降低；在使用二丙酸倍氯米松治疗期间，有4例患者出现这种情况。得出的结论是，尽管这两种药物通常是安全的，但每天两次给予200微克剂量时，两者都可能引起轻度肾上腺抑制。
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