Godfrey S, König P
Arch Dis Child. 1974 Aug;49(8):591-6. doi: 10.1136/adc.49.8.591.
Twenty-six children with asthma were treated with beclomethasone dipropionate aerosol in a dose adjusted to their symptoms for 13 to 20 months. 18 children in the group had been taking systemic steroids at the start of the trial and all were successfully weaned off them, mostly within 2 months. All but 1 of the children were satisfactorily controlled by beclomethasone, but 15 children needed short courses of oral steroids at times of severe exacerbations. There was no evidence of either suppression or acceleration of growth, nor was there any adrenal suppression as assessed at intervals by the estimation of the resting level of plasma cortisol and the response to tetracosactrin. No other side effects were encountered apart from exacerbations of eczema or rhinitis in some children previously on systemic steroids.
26名哮喘儿童接受了丙酸倍氯米松气雾剂治疗，剂量根据症状调整，治疗时间为13至20个月。该组中有18名儿童在试验开始时一直在服用全身性类固醇，所有儿童均成功停用，大多数在2个月内停用。除1名儿童外，所有儿童的病情均通过倍氯米松得到满意控制，但有15名儿童在病情严重加重时需要短期口服类固醇治疗。没有证据表明生长受到抑制或加速，通过测定血浆皮质醇静息水平和对二十四肽促皮质素的反应定期评估，也没有肾上腺抑制的情况。除了一些之前服用全身性类固醇的儿童出现湿疹或鼻炎加重外，未发现其他副作用。
