Barantsevich E R, Tomson V V, Sorokoumov V A, Skoromets A A, Valeev R I
Arkh Patol. 1987;49(7):60-4.
Activity of some enzymes in the cerebral cortex of rats with experimentally induced renal arterial hypertension (AH) was studied histochemically. Histologic data provide the evidence for the disturbances in water-salt metabolism in AH. Morphometric study revealed an increase in the specific volume of smaller microvessels and moderate decrease in the specific volume of bigger microvessels. Vascular markers show different time course of activity changes in AH: the activity of alkaline phosphatase increases, while that of alpha-glycerophosphate dehydrogenase remains unchanged. The development of AH is accompanied by the increase in succinic dehydrogenase activity and the decrease in the activity of lactate dehydrogenase in neurons. The changes in the neuron-capillary relationship arising in AH can be one of the possible pathogenetic factors in the pathologic process progression.
采用组织化学方法研究了实验性肾性动脉高血压（AH）大鼠大脑皮质中某些酶的活性。组织学数据为AH中水电解质代谢紊乱提供了证据。形态计量学研究显示，较小微血管的比容增加，较大微血管的比容适度降低。血管标志物显示AH中活性变化的时间进程不同：碱性磷酸酶的活性增加，而α-甘油磷酸脱氢酶的活性保持不变。AH的发展伴随着神经元中琥珀酸脱氢酶活性的增加和乳酸脱氢酶活性的降低。AH中神经元与毛细血管关系的变化可能是病理过程进展中可能的致病因素之一。
