Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China; National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin 300384, China.
Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300354, China.
J Biomech Eng. 2023 May 1;145(5). doi: 10.1115/1.4056658.
The lack of sufficient mechanical stimulation to the human bone, results in disuse osteoporosis. Low-intensity pulsed ultrasound (LIPUS) promotes fracture healing and the treatment of disuse osteoporosis, but its biomechanical mechanism remains unknown. Simulative research on the mechanical effects of LIPUS on disuse trabecular bone and osteoblasts have been performed. The von Mises stress of disuse trabecular bone and osteoblasts obviously increased under LIPUS irradiation. The average von Mises stress of osteoblasts were two orders of magnitude higher under the irradiation of simulant LIPUS than that without LIPUS irradiation, and the von Mises stress of osteoblasts was positively correlated with the amplitude of sound pressure excitation. The results showed that LIPUS irradiation could obviously improve the mechanical micro-environment of trabecular bone and osteoblasts to alleviate the lack of mechanical stimulation. The results of the research can reveal the biomechanical mechanism of LIPUS in the treatment of disuse osteoporosis to some extent and provide theoretical guidance for clinical treatment of disuse osteoporosis through physical methods.
缺乏足够的机械刺激会导致人体骨骼废用性骨质疏松。低强度脉冲超声（LIPUS）可促进骨折愈合和治疗废用性骨质疏松症，但它的生物力学机制尚不清楚。已经对 LIPUS 对废用性小梁骨和成骨细胞的力学效应进行了模拟研究。在 LIPUS 照射下，废用小梁骨和成骨细胞的 von Mises 应力明显增加。在模拟 LIPUS 照射下，成骨细胞的平均 von Mises 应力比没有 LIPUS 照射时高出两个数量级，且成骨细胞的 von Mises 应力与声压激励幅度呈正相关。结果表明，LIPUS 照射可明显改善小梁骨和成骨细胞的力学微环境，缓解机械刺激不足。该研究结果在一定程度上揭示了 LIPUS 治疗废用性骨质疏松症的生物力学机制，可为通过物理方法治疗废用性骨质疏松症提供理论指导。
