Haque Md Atiqul, Salwa Marium, Islam Mohammad Tanvir, Sultana Sarmin, Rahman Farhana, Ahmed Shamim, Haque Khan Md Maruf, Mosharraf Hossain A Km, Al Mamun Mohammad Abdullah, Bhuiyan Mahfuzur Rahman, Choudhury Sohel Reza
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
National Heart Foundation and Research Institute, Dhaka, Bangladesh.
Lung India. 2022 Nov-Dec;39(6):537-544. doi: 10.4103/lungindia.lungindia_300_22.
In Bangladesh, there is a scarcity of nationally representative data on the burden of chronic obstructive pulmonary disease (COPD).
To estimate the COPD prevalence in rural settings, this cross-sectional, population-based study was conducted in all eight administrative divisions of Bangladesh, and involved adults aged 40 years and above. By using multi-stage random sampling, 2,458 individuals were enrolled. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines were used to diagnose COPD based on post-bronchodilator lung function, while additional participant data was gathered through computer-assisted personal interviews.
A 2% COPD prevalence (95% CI: 1.45, 2.55) was found in the study sample with a statistically significant difference between males (2.7%; 95% CI: 1.8, 3.6) and females (1.2%; 95% CI: 0.59, 1.81). Increasing age significantly inflated the odds of having COPD irrespective of sex (OR: 1.03; 95% CI: 1.00, 1.05; P value < 0.05). Furthermore, prevalence of COPD was higher among manual workers, cigarette smokers, and those that used the indoor kitchen and did not have a primary education. Sex-based analysis showed that smokeless tobacco consumption was significantly associated with COPD occurrence among males (OR: 2.14; 95% CI: 1.05, 4.37; P value < 0.05), but not females. Further, using an indoor kitchen increased the odds of developing COPD by 400% among female participants (OR: 4.39; 95% CI: 1.37, 14.10; P value < 0.05).
This study provides a comprehensive sex-based estimation of COPD prevalence among rural population and imparts significant contribution to the growing database on COPD prevalence in Bangladesh.
在孟加拉国，缺乏关于慢性阻塞性肺疾病（COPD）负担的全国代表性数据。
为了估计农村地区的慢性阻塞性肺疾病患病率，在孟加拉国所有八个行政区开展了这项基于人群的横断面研究，研究对象为40岁及以上的成年人。采用多阶段随机抽样，纳入了2458名个体。根据支气管扩张剂使用后的肺功能，采用慢性阻塞性肺疾病全球倡议（GOLD）指南诊断慢性阻塞性肺疾病，同时通过计算机辅助个人访谈收集其他参与者数据。
研究样本中慢性阻塞性肺疾病患病率为2%（95%CI：1.45，2.55），男性（2.7%；95%CI：1.8，3.6）和女性（1.2%；95%CI：0.59，1.81）之间存在统计学显著差异。无论性别，年龄增长都会显著增加患慢性阻塞性肺疾病的几率（OR：1.03；95%CI：1.00，1.05；P值<0.05）。此外，体力劳动者、吸烟者以及使用室内厨房且未接受过初等教育的人群中慢性阻塞性肺疾病患病率更高。基于性别的分析表明，无烟烟草消费与男性慢性阻塞性肺疾病的发生显著相关（OR：2.14；95%CI：1.05，4.37；P值<0.05），但与女性无关。此外，在女性参与者中，使用室内厨房使患慢性阻塞性肺疾病的几率增加了400%（OR：4.39；95%CI：1.37，14.10；P值<0.05）。
本研究提供了基于性别的农村人口慢性阻塞性肺疾病患病率的全面估计，为孟加拉国不断增长的慢性阻塞性肺疾病患病率数据库做出了重要贡献。
