Karim Azmat, Shameem Mohammd, Khan Abdul Allam
Research Scholar, Department of Respiratory Medicine, Jawahar Lal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Department of Respiratory Medicine, Jawahar Lal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Lung India. 2022 Nov-Dec;39(6):578-580. doi: 10.4103/lungindia.lungindia_272_22.
Interleukin (IL)-5 plays an important role in development, recruitment, and survival of eosinophils, thereby causing debilitating signs and symptoms associated with severe eosinophilic asthma. Mepolizumab is a humanized monoclonal antibody (mAb) against IL-5 which selectively inhibits eosinophilic inflammation and reduces the amount of eosinophils. This reduction is seen in both sputum and blood, resulting in a reduction in exacerbations and in time the need for using systemic steroids. The role of mepolizumab and its effect is still not fully known as there are less real-life studies available. We herewith present a case of severe eosinophilic asthma with vocal polyp managed by mepolizumab.
白细胞介素（IL）-5在嗜酸性粒细胞的发育、募集和存活中起重要作用，从而导致与严重嗜酸性粒细胞性哮喘相关的衰弱体征和症状。美泊利珠单抗是一种抗IL-5的人源化单克隆抗体（mAb），它选择性抑制嗜酸性粒细胞炎症并减少嗜酸性粒细胞数量。痰液和血液中的嗜酸性粒细胞数量均可见减少，从而减少病情加重次数，并随着时间推移减少使用全身性类固醇的必要性。由于可用的实际研究较少，美泊利珠单抗的作用及其效果仍不完全清楚。我们在此介绍一例使用美泊利珠单抗治疗的伴有声带息肉的严重嗜酸性粒细胞性哮喘病例。
