Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology.
Proc Jpn Acad Ser B Phys Biol Sci. 2023;99(1):29-38. doi: 10.2183/pjab.99.002.
Micelles are useful and widely applied molecular assemblies, formed from amphiphilic molecules, in water. The majority of amphiphiles possess an alkyl chain as the hydrophobic part. Amphiphiles bearing hydrophilic and hydrophobic polymer chains generate so-called polymeric micelles in water. This review focuses on the recent progress of "aromatic micelles", formed from bent polyaromatic/aromatic amphiphiles, for the development of third-generation micelles. Thanks to multiple host-guest interactions, e.g., the hydrophobic effect and π-π/CH-π interactions, the present micelles display wide-ranging uptake abilities toward various hydrophobic compounds in water. In addition to such host functions, new stimuli-responsive aromatic micelles with pH, light, and redox switches, aromatic oligomer micelles, saccharide-coated aromatic micelles, and related cycloalkane-based micelles were recently developed by our group.
胶束是由两亲性分子在水中形成的有用且广泛应用的分子组装体。大多数两亲分子都具有烷基链作为疏水区。带有亲水和疏水聚合物链的两亲分子在水中生成所谓的聚合物胶束。本综述重点介绍了由弯曲的多环芳烃/芳烃两亲分子形成的“芳香族胶束”在第三代胶束发展方面的最新进展。由于存在多种主客体相互作用，例如疏水性和π-π/CH-π相互作用，这些胶束在水中对各种疏水性化合物具有广泛的摄取能力。除了这些主体功能外，我们小组最近还开发了具有 pH 值、光和氧化还原开关、芳香族低聚物胶束、糖包覆的芳香族胶束以及相关的环烷烃基胶束等新型刺激响应性芳香族胶束。
