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Toxic effects of ozone on murine L929 fibroblasts. Damaging action on transmembrane transport systems.臭氧对小鼠L929成纤维细胞的毒性作用。对跨膜转运系统的破坏作用。
Biochem J. 1987 Jul 1;245(1):301-4. doi: 10.1042/bj2450301.
2
Damaging action of photodynamic treatment in combination with hyperthermia on transmembrane transport in murine L929 fibroblasts.
Biochim Biophys Acta. 1989 Feb 27;979(2):215-20. doi: 10.1016/0005-2736(89)90437-9.
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Photodynamic effects of hematoporphyrin-derivative on transmembrane transport systems of murine L929 fibroblasts.血卟啉衍生物对小鼠L929成纤维细胞跨膜转运系统的光动力效应。
Biochim Biophys Acta. 1984 Apr 11;771(2):201-7. doi: 10.1016/0005-2736(84)90534-0.
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Insulin stimulation of glucose and amino acid transport in mouse fibroblasts with elevated membrane microviscosity.胰岛素对膜微粘度升高的小鼠成纤维细胞中葡萄糖和氨基酸转运的刺激作用。
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Early decrease of 2-deoxy glucose and alpha-amino isobutyric acid transport are among the first events in differentiating synchronized murine erythroleukemia cells.在同步化的小鼠红白血病细胞分化过程中，2-脱氧葡萄糖和α-氨基异丁酸转运的早期减少是最早出现的事件之一。
J Cell Physiol. 1979 Jun;99(3):407-16. doi: 10.1002/jcp.1040990315.
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Toxic effects of ozone on murine L929 fibroblasts. Enzyme inactivation and glutathione depletion.臭氧对小鼠L929成纤维细胞的毒性作用。酶失活与谷胱甘肽耗竭。
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Amino acid transport and rubidium-ion uptake in monolayer cultures of hepatocytes from neonatal rats.新生大鼠肝细胞单层培养物中的氨基酸转运和铷离子摄取
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Energetics of amino acid transport into brain slices: effects of K+ depletion and Rb+ or Cs+ substitution on amino acid uptake.
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Glucose enhancement of insulin action: elevated glucose levels increase insulin stimulation of 2-deoxyglucose uptake in cultured human fibroblasts.葡萄糖对胰岛素作用的增强：血糖水平升高会增加胰岛素对培养的人成纤维细胞摄取2-脱氧葡萄糖的刺激作用。
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Insulin-induced insulin resistance of alpha-aminoisobutyric acid transport in cultured human skin fibroblasts.胰岛素诱导的培养人皮肤成纤维细胞中α-氨基异丁酸转运的胰岛素抵抗
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引用本文的文献

1
Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA.臭氧对小鼠L929成纤维细胞的毒性作用。对DNA的损伤。
Biochem J. 1987 Oct 1;247(1):69-72. doi: 10.1042/bj2470069.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Kinetic analysis of H+/methyl beta-D-thiogalactoside symport in Saccharomyces fragilis.脆壁酵母中H⁺/甲基-β-D-硫代半乳糖苷同向转运的动力学分析
Biochim Biophys Acta. 1982 Dec 8;693(1):213-20. doi: 10.1016/0005-2736(82)90489-8.
3
[DNA degradation and survival of ozone-resistant and -sensitive mutants isolated in Escherichia coli B (author's transl)].[在大肠杆菌B中分离出的耐臭氧和对臭氧敏感的突变体的DNA降解与存活情况（作者译）]
Mol Gen Genet. 1981;184(3):560-1. doi: 10.1007/BF00352541.
4
Lactose transport in Escherichia coli cells. Dependence of kinetic parameters on the transmembrane electrical potential difference.大肠杆菌细胞中的乳糖转运。动力学参数对跨膜电势差的依赖性。
Biochim Biophys Acta. 1981 Jun 22;644(2):305-15. doi: 10.1016/0005-2736(81)90388-6.
5
Degradation of nucleic acids with ozone. VI. Labilization of the double-helical structure of calf thymus deoxyribonucleic acid.
Chem Pharm Bull (Tokyo). 1984 Sep;32(9):3636-40. doi: 10.1248/cpb.32.3636.
6
Kinetic analysis of simultaneously occurring proton-sorbose symport and passive sorbose transport in Saccharomyces fragilis.脆壁酵母中同时发生的质子-山梨糖同向转运和被动山梨糖转运的动力学分析。
Biochim Biophys Acta. 1980 Nov 4;602(2):419-32. doi: 10.1016/0005-2736(80)90321-1.
7
Photodynamic effects of hematoporphyrin-derivative on transmembrane transport systems of murine L929 fibroblasts.血卟啉衍生物对小鼠L929成纤维细胞跨膜转运系统的光动力效应。
Biochim Biophys Acta. 1984 Apr 11;771(2):201-7. doi: 10.1016/0005-2736(84)90534-0.
8
The autoxidation of human red cell lipids induced by hydrogen peroxide.过氧化氢诱导的人红细胞脂质自氧化。
Br J Haematol. 1971 Jan;20(1):95-111. doi: 10.1111/j.1365-2141.1971.tb00790.x.
9
Reaction of ozone with amino acids and proteins.臭氧与氨基酸和蛋白质的反应。
Atmos Environ. 1969 Nov;3(6):669-82. doi: 10.1016/0004-6981(69)90024-9.
10
Coupling in secondary active transport. Activation of transport by co-transport and-or counter-transport with the fluxes of other solutes.
Biochim Biophys Acta. 1972 Feb 11;255(2):442-61. doi: 10.1016/0005-2736(72)90149-6.

臭氧对小鼠L929成纤维细胞的毒性作用。对跨膜转运系统的破坏作用。

Toxic effects of ozone on murine L929 fibroblasts. Damaging action on transmembrane transport systems.

作者信息

Van der Zee J, Dubbelman T M, Van Steveninck J

机构信息

Sylvius Laboratories, Department of Medical Biochemistry, Leiden, The Netherlands.

出版信息

Biochem J. 1987 Jul 1;245(1):301-4. doi: 10.1042/bj2450301.

DOI:10.1042/bj2450301
PMID:3663156
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148117/
Abstract

Exposure of murine L929 fibroblasts to ozone caused inactivation of the energy-coupled transport systems for 2-aminoisobutyric acid and Rb+. Ozone induced an increase of the apparent Km for 2-aminoisobutyric acid transport, with a constant Vmax, indicating impairment of the carrier function, rather than a decrease in the number of transport sites. The uptake rate of 2-deoxy-D-glucose, on the other hand, increased after exposure of the cells to ozone. This was caused by an increased Vmax. of facilitated diffusion, without increased after ozone exposure. Together with the K+ leakage described previously, this reflects ozone-induced impairment of the barrier function of the membrane.

摘要

将鼠源L929成纤维细胞暴露于臭氧中会导致2-氨基异丁酸和Rb⁺的能量偶联转运系统失活。臭氧使2-氨基异丁酸转运的表观Km增加，而Vmax恒定，这表明载体功能受损，而非转运位点数量减少。另一方面，细胞暴露于臭氧后，2-脱氧-D-葡萄糖的摄取速率增加。这是由易化扩散的Vmax增加所致，臭氧暴露后其数量并未增加。连同之前描述的K⁺泄漏，这反映了臭氧诱导的细胞膜屏障功能受损。