• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多巴胺受体支持颞叶-海马CA1突触内在兴奋性的增强和突触长时程抑制。

Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse.

作者信息

Kim Hye-Hyun, Lee Suk-Ho, Ho Won-Kyung, Eom Kisang

机构信息

Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Neuroscience Research Center, Seoul National University College of Medicine, Seoul 03080, Korea.

出版信息

Exp Neurobiol. 2022 Dec 31;31(6):361-375. doi: 10.5607/en22028.

DOI:10.5607/en22028
PMID:36631845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9841748/
Abstract

Dopaminergic projection to the hippocampus from the ventral tegmental area or locus ceruleus has been considered to play an essential role in the acquisition of novel information. Hence, the dopaminergic modulation of synaptic plasticity in the hippocampus has been widely studied. We examined how the D1 and D2 receptors influenced the mGluR5-mediated synaptic plasticity of the temporoammonic-CA1 synapses and showed that the dopaminergic modulation of the temporoammonic-CA1 synapses was expressed in various ways. Our findings suggest that the dopaminergic system in the hippocampal CA1 region regulates the long-term synaptic plasticity and processing of the novel information.

摘要

来自腹侧被盖区或蓝斑的多巴胺能投射至海马体，这一过程被认为在新信息获取中起着至关重要的作用。因此，海马体中多巴胺能对突触可塑性的调节作用已得到广泛研究。我们研究了D1和D2受体如何影响颞叶-海马- CA1突触中代谢型谷氨酸受体5（mGluR5）介导的突触可塑性，并表明多巴胺能对颞叶-海马- CA1突触的调节以多种方式表现出来。我们的研究结果表明，海马CA1区的多巴胺能系统调节长期突触可塑性及新信息的处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/023dfce3ac97/en-31-6-361-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/3a82987052bc/en-31-6-361-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/f498e57a97a9/en-31-6-361-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/e85db9e8586b/en-31-6-361-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/7669c50b8fa3/en-31-6-361-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/023dfce3ac97/en-31-6-361-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/3a82987052bc/en-31-6-361-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/f498e57a97a9/en-31-6-361-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/e85db9e8586b/en-31-6-361-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/7669c50b8fa3/en-31-6-361-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8419/9841748/023dfce3ac97/en-31-6-361-f5.jpg

相似文献

1
Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse.多巴胺受体支持颞叶-海马CA1突触内在兴奋性的增强和突触长时程抑制。
Exp Neurobiol. 2022 Dec 31;31(6):361-375. doi: 10.5607/en22028.
2
Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression.多巴胺D1/D5受体通过海马体的长时程增强和长时程抑制来控制新信息的获取。
J Neurosci. 2006 Jul 19;26(29):7723-9. doi: 10.1523/JNEUROSCI.1454-06.2006.
3
Antagonism of D1/D5 receptors prevents long-term depression (LTD) and learning-facilitated LTD at the perforant path-dentate gyrus synapse in freely behaving rats.拮抗D1/D5受体可阻止自由活动大鼠在穿通通路-齿状回突触处发生长时程抑制（LTD）以及学习促进型LTD。
Hippocampus. 2014 Dec;24(12):1615-22. doi: 10.1002/hipo.22340. Epub 2014 Aug 27.
4
Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors, metabotropic glutamate receptors and voltage-gated calcium channels.在体内，海马体CA1区颞叶-听觉输入处的突触强度受N-甲基-D-天冬氨酸（NMDA）受体、代谢型谷氨酸受体和电压门控钙通道调控。
Neuroscience. 2015 Nov 19;309:191-9. doi: 10.1016/j.neuroscience.2015.03.014. Epub 2015 Mar 17.
5
The temporoammonic input to the hippocampal CA1 region displays distinctly different synaptic plasticity compared to the Schaffer collateral input in vivo: significance for synaptic information processing.颞叶内上回至海马 CA1 区的传入与在体的 Schaffer 侧枝传入相比表现出明显不同的突触可塑性：对突触信息处理的意义。
Front Synaptic Neurosci. 2013 Aug 23;5:5. doi: 10.3389/fnsyn.2013.00005. eCollection 2013.
6
A computational model of dopaminergic modulation of hippocampal Schaffer collateral-CA1 long-term plasticity.多巴胺调制海马 CA1 长时程可塑性的计算模型。
J Comput Neurosci. 2022 Feb;50(1):51-90. doi: 10.1007/s10827-021-00793-6. Epub 2021 Aug 25.
7
Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses.经典的JAK-STAT信号传导对于成年海马颞叶-海马体CA1突触的长期抑制至关重要。
FASEB J. 2017 Aug;31(8):3449-3466. doi: 10.1096/fj.201601293RR. Epub 2017 May 1.
8
Dopamine D1/D5, But not D2/D3, Receptor Dependency of Synaptic Plasticity at Hippocampal Mossy Fiber Synapses that Is Enabled by Patterned Afferent Stimulation, or Spatial Learning.海马苔藓纤维突触处突触可塑性的多巴胺D1/D5而非D2/D3受体依赖性，其由模式化传入刺激或空间学习所促成。
Front Synaptic Neurosci. 2016 Sep 23;8:31. doi: 10.3389/fnsyn.2016.00031. eCollection 2016.
9
Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses: roles of N-methyl-D-aspartate and metabotropic glutamate receptors.条件刺激引起的海马 CA1 突触中不同脉冲数的双向突触可塑性：N-甲基-D-天冬氨酸和代谢型谷氨酸受体的作用。
Synapse. 2011 Aug;65(8):795-803. doi: 10.1002/syn.20906. Epub 2011 Mar 10.
10
Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons.直接的皮质输入调节CA1锥体神经元的可塑性和放电。
Nature. 2002 Apr 18;416(6882):736-40. doi: 10.1038/416736a.

引用本文的文献

1
Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer's disease mouse model.对蓝斑CA1儿茶酚胺能终末进行光刺激可逆转阿尔茨海默病小鼠模型中的空间记忆障碍。
Psychopharmacology (Berl). 2025 Sep 8. doi: 10.1007/s00213-025-06885-w.
2
Unraveling the Mechanisms of Cannabidiol's Pharmacological Actions: A Comprehensive Research Overview.解析大麻二酚药理作用的机制：全面的研究综述。
Top Curr Chem (Cham). 2024 Jun 3;382(2):20. doi: 10.1007/s41061-024-00465-w.
3
Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations.

本文引用的文献

1
Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories.中脑多巴胺能神经支配海马足以调节厌恶记忆的形成。
Proc Natl Acad Sci U S A. 2021 Oct 5;118(40). doi: 10.1073/pnas.2111069118.
2
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus.PKA 驱动海马体 LTP 期间 AMPA 受体单通道电导的增加。
Nat Commun. 2021 Jan 18;12(1):413. doi: 10.1038/s41467-020-20523-3.
3
LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields.
埃坡霉素-D单独以及在淀粉样β蛋白和tau蛋白诱导的改变背景下的有害和保护作用。
Front Mol Neurosci. 2023 Oct 12;16:1198299. doi: 10.3389/fnmol.2023.1198299. eCollection 2023.
LTD 参与了大鼠海马 CA1 位置细胞场的形成和维持。
Nat Commun. 2021 Jan 4;12(1):100. doi: 10.1038/s41467-020-20317-7.
4
Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse.多巴胺 D2 受体在海马依赖性记忆和 CA3-CA1 突触可塑性中是必需的。
Cereb Cortex. 2021 Mar 5;31(4):2187-2204. doi: 10.1093/cercor/bhaa354.
5
Voltage-Dependent Dopamine Potency at D-Like Dopamine Receptors.D型多巴胺受体上的电压依赖性多巴胺效能
Front Pharmacol. 2020 Oct 7;11:581151. doi: 10.3389/fphar.2020.581151. eCollection 2020.
6
Increase in excitability of hippocampal neurons during novelty-induced hyperlocomotion in dopamine-deficient mice.在多巴胺缺乏的小鼠中，新奇诱导的过度活跃期间海马神经元兴奋性增加。
Mol Brain. 2020 Sep 18;13(1):126. doi: 10.1186/s13041-020-00664-8.
7
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.D2 多巴胺受体- G 蛋白复合物在脂质膜中的结构。
Nature. 2020 Aug;584(7819):125-129. doi: 10.1038/s41586-020-2379-5. Epub 2020 Jun 11.
8
Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus.内源性大麻素长时程抑制揭示在齿状回的内侧穿通纤维兴奋性突触传递。
Neuropharmacology. 2019 Jul 15;153:32-40. doi: 10.1016/j.neuropharm.2019.04.020. Epub 2019 Apr 22.
9
Association of mGluR-Dependent LTD of Excitatory Synapses with Endocannabinoid-Dependent LTD of Inhibitory Synapses Leads to EPSP to Spike Potentiation in CA1 Pyramidal Neurons.谷氨酸能受体依赖的兴奋性突触 LTD 与内源性大麻素依赖的抑制性突触 LTD 的关联导致 CA1 锥体神经元中的 EPSP 到尖峰的增强。
J Neurosci. 2019 Jan 9;39(2):224-237. doi: 10.1523/JNEUROSCI.2935-17.2018. Epub 2018 Nov 20.
10
Neuromodulation of hippocampal long-term synaptic plasticity.海马体长时程突触可塑性的神经调节。
Curr Opin Neurobiol. 2019 Feb;54:37-43. doi: 10.1016/j.conb.2018.08.009. Epub 2018 Sep 10.