Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 10081, China.
Top Curr Chem (Cham). 2024 Jun 3;382(2):20. doi: 10.1007/s41061-024-00465-w.
Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.
大麻长期以来一直被用于神经和心理治疗。最近，从大麻中提取的大麻二酚（CBD）因其对中枢和外周神经系统的非精神活性治疗作用而在医学领域引起关注。CBD 还具有强大的抗氧化作用，具有多种临床特性，如抗癌、抗炎、抗抑郁、抗氧化、止吐、抗焦虑、抗癫痫和抗精神病作用。在这篇综述中，我们通过实验和计算技术总结了 CBD 与不同受体的结构活性关系，并研究了相关受体与 CBD 之间相互作用的机制。CBD 与靶受体之间结构活性关系的发现将为优化 CBD 及其衍生物的骨架提供方向，从而为基于 CBD 的各种疾病治疗方法提供潜在的医学应用。
