Department of Computer Science, University of Victoria, Victoria, BC, Canada.
CSAIL, MIT, Cambridge, MA, USA.
Genome Biol. 2023 Jan 11;24(1):5. doi: 10.1186/s13059-022-02841-5.
Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing performant MPC applications. Sequre offers a set of automatic compile-time optimizations that significantly improve the performance of MPC applications and incorporates the syntax of Python programming language to facilitate rapid application development. We demonstrate its usability and performance on various bioinformatics tasks showing up to 3-4 times increased speed over the existing pipelines with 7-fold reductions in codebase sizes.
安全多方计算（MPC）是一种加密工具，可在敏感的生物医学数据上进行计算，而不会向参与实体透露私人信息。在这里，我们引入了 Sequre，这是一个易于使用、高性能的框架，用于开发高性能的 MPC 应用程序。Sequre 提供了一组自动的编译时优化，可显著提高 MPC 应用程序的性能，并采用 Python 编程语言的语法，以方便快速开发应用程序。我们在各种生物信息学任务上展示了它的可用性和性能，与现有流水线相比，速度提高了 3-4 倍，代码库大小减少了 7 倍。
