视黄醇缺乏及姜黄素/姜黄喂养对大鼠组织微粒体膜脂质过氧化和脂肪酸的影响。
Influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats.
作者信息
Kaul S, Krishnakantha T P
机构信息
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
出版信息
Mol Cell Biochem. 1997 Oct;175(1-2):43-8. doi: 10.1023/a:1006829010327.
The effect of retinol deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% in spleen and 16.0 or 31.4% in brain. Retinol deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels.
研究了视黄醇缺乏以及姜黄素/姜黄对大鼠肝脏、肾脏、脾脏和脑微粒体中脂质过氧化和脂肪酸谱的影响。结果显示，与对照组相比，视黄醇缺乏的大鼠肝脏、肾脏、脾脏和脑中的脂质过氧化分别增加了32%、30%、24%和43%。给视黄醇缺乏的大鼠喂食含0.1%姜黄素或姜黄的饲料三周后，肝脏中的脂质过氧化分别降至12.5%或22.6%，肾脏中降至23.7%或24.1%，脾脏中降至14.4%或18.0%，脑中降至16.0%或31.4%。视黄醇缺乏导致必需脂肪酸减少。在肝脏中，C18:1减少了45.6%，C18:2减少了31.6%，C20:4减少了22.8%。在肾脏中，C18:1减少了33.6%，18:2减少了24.6%，20:4减少了13.7%。在脾脏和脑中，C18:1分别减少了10.2%和33.9%，C18:2分别减少了37.9%和12.1%，C20:4分别减少了15.7%和35.3%。喂食姜黄素和姜黄的组中，异常降低的脂肪酸水平显著增加。
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