Bellentani S, Chao Y C, Ferretti I, Panini R, Tiribelli C
Fondo Studi Fegato, Modena-Trieste, Italy.
Biochem Biophys Res Commun. 1996 Mar 27;220(3):479-83. doi: 10.1006/bbrc.1996.0430.
We studied the effect of oral supplementation with ursodeoxycholate (UDCA) or tauroursodeoxycholate (TUDCA) on the lipid content and fatty acid composition of rat hepatic microsomes. UDCA and TUDCA significantly increased the total amount of lipids with the exception of cholesteryl-esters. UDCA significantly increased the triglycerides and phosphatidylethanolamine (PE) microsomal content, and decreased the cholesterol/phospholipids and the phosphatidylcholine (PC)/PE ratio. Both treatments increased the percentage oleic acid and of polyunsaturated fatty acids (PUFA) in each class of lipids. UDCA and TUDCA had a different action on PUFA microsomal molar percentage of phospholipids: UDCA increased the relative percentage of PUFA in the PE fraction, while TUDCA increased the relative percentage of PUFA in the PC fraction. These changes in the hepatic lipid content and composition might in part explain both cytoprotective action of these hydrophillic bile acids and their effect on membrane fluidity.
我们研究了口服补充熊去氧胆酸（UDCA）或牛磺熊去氧胆酸（TUDCA）对大鼠肝微粒体脂质含量和脂肪酸组成的影响。除胆固醇酯外，UDCA和TUDCA均显著增加了脂质总量。UDCA显著增加了甘油三酯和磷脂酰乙醇胺（PE）的微粒体含量，并降低了胆固醇/磷脂以及磷脂酰胆碱（PC）/PE的比例。两种处理均增加了各类脂质中油酸和多不饱和脂肪酸（PUFA）的百分比。UDCA和TUDCA对磷脂中PUFA微粒体摩尔百分比有不同作用：UDCA增加了PE组分中PUFA的相对百分比，而TUDCA增加了PC组分中PUFA的相对百分比。肝脂质含量和组成的这些变化可能部分解释了这些亲水性胆汁酸的细胞保护作用及其对膜流动性的影响。
