Beretta C, Fadini L, Stracciari J M, Montesissa C
Institute of Veterinary Pharmacology and Toxicology, University of Milan, Italy.
Biochem Pharmacol. 1987 Oct 1;36(19):3107-14. doi: 10.1016/0006-2952(87)90619-8.
Febantel and one of its main metabolites, febantel sulphoxide, are chemically modified to only a slight extent when incubated in vitro with sheep and cattle ruminal fluids; other major metabolites, fenbendazole and oxfendazole, are respectively, oxidized to oxfendazole and reduced to fenbendazole. Febantel is negligibly metabolized by hepatic cytosol fractions but microsome preparations effect more extensive metabolic transformations. Important differences in this respect were found between microsome preparations from rat, horse, pig, cattle, sheep, chicken and trout livers.
非班太尔及其主要代谢产物之一非班太尔亚砜，与绵羊和牛的瘤胃液在体外孵育时，化学修饰程度很小；其他主要代谢产物芬苯达唑和奥芬达唑则分别被氧化为奥芬达唑和还原为芬苯达唑。非班太尔在肝细胞溶质组分中的代谢可忽略不计，但微粒体制剂会产生更广泛的代谢转化。在大鼠、马、猪、牛、羊、鸡和鳟鱼肝脏的微粒体制剂之间发现了这方面的重要差异。
