Sartin Samantha, Ranzini Mariagrazia, Scarpazza Cristina, Monaco Simona
CIMeC - Center for Mind/Brain Sciences, University of Trento, Italy.
Department of Neuroscience (DNS), University of Padua, Italy.
Curr Res Neurobiol. 2022 Dec 30;4:100070. doi: 10.1016/j.crneur.2022.100070. eCollection 2023.
The functional specialization of the ventral stream in Perception and the dorsal stream in Action is the cornerstone of the leading model proposed by Goodale and Milner in 1992. This model is based on neuropsychological evidence and has been a matter of debate for almost three decades, during which the dual-visual stream hypothesis has received much attention, including support and criticism. The advent of functional magnetic resonance imaging (fMRI) has allowed investigating the brain areas involved in Perception and Action, and provided useful data on the functional specialization of the two streams. Research on this topic has been quite prolific, yet no meta-analysis so far has explored the spatial convergence in the involvement of the two streams in Action. The present meta-analysis (N = 53 fMRI and PET studies) was designed to reveal the specific neural activations associated with Action (i.e., grasping and reaching movements), and the extent to which visual information affects the involvement of the two streams during motor control. Our results provide a comprehensive view of the consistent and spatially convergent neural correlates of Action based on neuroimaging studies conducted over the past two decades. In particular, occipital-temporal areas showed higher activation likelihood in the Vision compared to the No vision condition, but no difference between reach and grasp actions. Frontal-parietal areas were consistently involved in both reach and grasp actions regardless of visual availability. We discuss our results in light of the well-established dual-visual stream model and frame these findings in the context of recent discoveries obtained with advanced fMRI methods, such as multivoxel pattern analysis.
腹侧流在感知方面和背侧流在动作方面的功能特化是古德尔和米尔纳于1992年提出的主导模型的基石。该模型基于神经心理学证据，近三十年来一直是一个有争议的问题，在此期间，双视觉流假说受到了广泛关注，既有支持也有批评。功能磁共振成像（fMRI）的出现使得研究参与感知和动作的脑区成为可能，并为这两个视觉流的功能特化提供了有用的数据。关于这个主题的研究成果颇丰，但到目前为止还没有荟萃分析探讨这两个视觉流在动作中的空间收敛情况。本荟萃分析（N = 53项fMRI和PET研究）旨在揭示与动作（即抓握和伸手动作）相关的特定神经激活，以及视觉信息在运动控制过程中影响这两个视觉流参与程度的情况。我们的结果基于过去二十年进行的神经影像学研究，提供了关于动作的一致且空间收敛的神经关联的全面观点。特别是，与无视觉条件相比，枕颞区在视觉条件下显示出更高的激活可能性，但伸手和抓握动作之间没有差异。无论视觉条件如何，额顶叶区域始终参与伸手和抓握动作。我们根据已确立的双视觉流模型讨论我们的结果，并将这些发现置于最近使用先进的fMRI方法（如多体素模式分析）获得的发现的背景下。
