Ruland Sabine H, Sigl Benjamin, Stangier Jeanette, Caspers Svenja, Bludau Sebastian, Mohlberg Hartmut, Pieperhoff Peter, Amunts Katrin
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Commun Biol. 2025 Aug 1;8(1):1143. doi: 10.1038/s42003-025-08528-4.
The premotor cortex is involved in a variety of motor and cognitive functions that often cannot be unambiguously linked to its microstructural correlates. We re-analysed the cytoarchitecture of this region in ten post mortem brains using an observer-independent mapping approach. Seven areas (6d1-6d3, 6v1-6v3, 6r1) were identified. Based on their cytoarchitectonic similarity, they were grouped into three dorsal (6d1-3) and four ventral (6v1-3, 6r1) premotor areas, supporting the concept of a functionally distinct dorsal and ventral premotor cortex. The superior frontal sulcus was identified as landmark for this separation. Comparison of the new maps with functional studies indicates that the frontal and inferior frontal eye fields are located within the premotor cortex, specifically in areas 6v1 and 6v2, not in the prefrontal cortex. Functional profiles of the areas were determined, serving as an initial basis for a more detailed characterisation of the individual areas. The new maps are publicly available to inform neuroimaging studies and aiding clinical applications such as targeting lesions or tumors and avoiding motor or cognitive impairments.
运动前区皮层参与多种运动和认知功能，而这些功能往往无法明确地与其微观结构特征联系起来。我们使用一种独立于观察者的映射方法，对10个死后大脑中该区域的细胞结构进行了重新分析。确定了7个区域（6d1 - 6d3、6v1 - 6v3、6r1）。基于它们的细胞结构相似性，将它们分为三个背侧（6d1 - 3）和四个腹侧（6v1 - 3、6r1）运动前区，支持了功能上不同的背侧和腹侧运动前区皮层的概念。中央前沟被确定为这种划分的标志。将新图谱与功能研究进行比较表明，额眼区和额下回眼区位于运动前区皮层内，具体在6v1和6v2区域，而非前额叶皮层。确定了这些区域的功能概况，为更详细地描述各个区域奠定了初步基础。新图谱已公开提供，以指导神经影像学研究，并辅助临床应用，如定位病变或肿瘤以及避免运动或认知障碍。
