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SIRT1 在内分泌和代谢疾病中的新作用。

Novel Role of the SIRT1 in Endocrine and Metabolic Diseases.

机构信息

Department of Cardiology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.

出版信息

Int J Biol Sci. 2023 Jan 1;19(2):484-501. doi: 10.7150/ijbs.78654. eCollection 2023.

DOI:10.7150/ijbs.78654
PMID:36632457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9830516/
Abstract

Silent information regulator 1 (SIRT1), a highly conserved NAD-dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism. The accumulated evidence suggests that SIRT1 is involved in the development of endocrine and metabolic diseases. In a variety of organisms, SIRT1 regulates gene expression through the deacetylation of histone, transcription factors, and lysine residues of other modified proteins including several metabolic and endocrine signal transcription factors, thereby enhancing the therapeutic effects of endocrine and metabolic diseases. These evidences indicate that targeting SIRT1 has promising applications in the treatment of endocrine and metabolic diseases. This review focuses on the role of SIRT1 in endocrine and metabolic diseases. First, we describe the background and structure of SIRT1. Then, we outline the role of SIRT1 in endocrine and metabolic diseases such as hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, and polycystic ovarian syndrome. Subsequently, the SIRT1 agonists and inhibitors in the above diseases are summarized and future research directions are proposed. Overall, the information presents here may highlight the potential of SIRT1 as a future biomarker and therapeutic target for endocrine and metabolic diseases.

摘要

沉默信息调节因子 1（SIRT1）是一种高度保守的 NAD 依赖性去乙酰化酶，作为细胞的调控因子，近年来受到广泛关注，被认为是细胞能量和代谢的传感器。大量证据表明，SIRT1 参与了内分泌和代谢疾病的发生发展。在多种生物中，SIRT1 通过去乙酰化组蛋白、转录因子和其他修饰蛋白的赖氨酸残基来调节基因表达，包括几种代谢和内分泌信号转录因子，从而增强了内分泌和代谢疾病的治疗效果。这些证据表明，靶向 SIRT1 在内分泌和代谢疾病的治疗中有广阔的应用前景。本综述重点关注 SIRT1 在内分泌和代谢疾病中的作用。首先，我们描述了 SIRT1 的背景和结构。然后，我们概述了 SIRT1 在高尿酸血症、糖尿病、高血压、高血脂、骨质疏松症和多囊卵巢综合征等内分泌和代谢疾病中的作用。随后，总结了上述疾病中 SIRT1 激动剂和抑制剂，并提出了未来的研究方向。总的来说，这里呈现的信息可能突出了 SIRT1 作为未来内分泌和代谢疾病生物标志物和治疗靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/48884803395f/ijbsv19p0484g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/05d2d7d2fe42/ijbsv19p0484g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/23c86a70c0a7/ijbsv19p0484g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/48884803395f/ijbsv19p0484g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/05d2d7d2fe42/ijbsv19p0484g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/23c86a70c0a7/ijbsv19p0484g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/337b/9830516/48884803395f/ijbsv19p0484g003.jpg

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Novel Role of the SIRT1 in Endocrine and Metabolic Diseases.

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[7]
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引用本文的文献

[1]
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies.

Hum Cell. 2025-9-7

[2]
Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.

Pharmaceuticals (Basel). 2025-8-19

[3]
Co-treatments of vitamin D and mesenchymal stem cells effectively alleviate the diabetic kidney disease through attenuating the SIRT1-mediated pathways.

Stem Cell Res Ther. 2025-8-26

[4]
Sirtuins in Central Nervous System Tumors-Molecular Mechanisms and Therapeutic Targeting.

Cells. 2025-7-19

[5]
Effect and mechanism of resveratrol against polycystic ovary syndrome: a review.

Front Endocrinol (Lausanne). 2025-7-7

[6]
Association between mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) and PCOS.

Eur J Med Res. 2025-7-10

[7]
Mechanistic Study on the Therapeutic Effects of Juanbi Lijieqing Formula in a Rat Model of Gouty Arthritis with Hyperuricemia.

J Pain Res. 2025-6-9

[8]
Capsaicin counteracts dexamethasone-induced osteoporosis and metabolic disturbances in rats: role of AMPK/SIRT1/β-catenin/RUNX2 pathway.

J Mol Histol. 2025-5-28

[9]
Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review).

Mol Med Rep. 2025-8

[10]
Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration.

J Nanobiotechnology. 2025-5-10

本文引用的文献

[1]
Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.

Front Immunol. 2022

[2]
Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.

Acta Biochim Biophys Sin (Shanghai). 2022-3-25

[3]
Genistein affects gonadotrophin-releasing hormone secretion in GT1-7 cells via modulating kisspeptin receptor and key regulators.

Syst Biol Reprod Med. 2022-4

[4]
Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

ACS Pharmacol Transl Sci. 2021-11-1

[5]
Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts.

Aging (Albany NY). 2021-10-28

[6]
Resveratrol (RV): A pharmacological review and call for further research.

Biomed Pharmacother. 2021-11

[7]
Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases.

Oxid Med Cell Longev. 2021

[8]
Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma.

Hepatology. 2021-12

[9]
Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies.

Reprod Sci. 2022-9

[10]
Cinnamon as Dietary Supplement Caused Hyperlipidemia in Healthy Rats.

Evid Based Complement Alternat Med. 2021-7-2

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