Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.
Front Immunol. 2024 Jul 16;15:1422541. doi: 10.3389/fimmu.2024.1422541. eCollection 2024.
The silent information regulator sirtuin 1 (SIRT1) protein is an NAD-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.
沉默信息调节因子 SIRT1（SIRT1）蛋白是一种 NAD 依赖性 III 类赖氨酸去乙酰化酶，作为一种重要的转录后修饰因子，靶向赖氨酸乙酰化位点，介导组蛋白和非组蛋白的去乙酰化修饰。SIRT1 已被报道参与几种生理或病理过程，如衰老、炎症、免疫反应、氧化应激和过敏性疾病。在这篇综述中，我们总结了 SIRT1 在过敏症进展过程中的调节作用。此外，我们还强调了靶向 SIRT1 在过敏性疾病中的治疗效果。
