Kyrodimos Efthymios, Chrysovergis Aristeidis, Mastronikolis Nicholas, Papanastasiou George, Tsiambas Evangelos, Spyropoulou Despoina, Katsinis Spyros, Manoli Arezina, Papouliakos Sotirios, Pantos Pavlos, Ragos Vasileios, Peschos Dimitrios, Papanikolaou Vasileios
First ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.
ENT Department, Medical School, University of Patras, Patras, Greece.
Cancer Diagn Progn. 2023 Jan 3;3(1):26-30. doi: 10.21873/cdp.10175. eCollection 2023 Jan-Feb.
Thyroid carcinoma represents a leading malignancy among those derived from human endocrine systems. It comprises a variety of different histological subtypes, including mainly papillary carcinoma, follicular carcinoma, anaplastic carcinoma, and medullar carcinoma. A broad spectrum of genetic imbalances, comprising gross chromosomal (polysomy/aneuploidy) and specific gene (mutations, amplifications, deletions) alterations, has been reported. Interestingly, the role of isolated, specific gene polymorphisms, especially of the single nucleotide polymorphism (SNP) type, in thyroid carcinoma is under investigation. SNPs are the most common genetic variations in the genome. The current molecular review focuses on the impact of specific SNPs on the biological behavior of papillary thyroid carcinoma in their carriers.
甲状腺癌是人类内分泌系统来源的主要恶性肿瘤之一。它包括多种不同的组织学亚型，主要有乳头状癌、滤泡状癌、未分化癌和髓样癌。据报道，存在广泛的基因失衡，包括染色体数目异常（多倍体/非整倍体）和特定基因（突变、扩增、缺失）改变。有趣的是，孤立的特定基因多态性，尤其是单核苷酸多态性（SNP）类型在甲状腺癌中的作用正在研究中。SNP是基因组中最常见的基因变异。当前的分子综述聚焦于特定SNP对其携带者甲状腺乳头状癌生物学行为的影响。
