术前D-二聚体水平在Ⅰ-Ⅲ期结直肠癌患者中的预后作用
Prognostic Role of Preoperative D-dimer Levels in Patients With Stage I-III Colorectal Cancer.
作者信息
Shibutani Masatsune, Kashiwagi Shinichiro, Fukuoka Tatsunari, Iseki Yasuhito, Kasashima Hiroaki, Kitayama Kishu, Maeda Kiyoshi
机构信息
Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Department of Breast and Endocrine Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
出版信息
Cancer Diagn Progn. 2023 Jan 3;3(1):38-43. doi: 10.21873/cdp.10177. eCollection 2023 Jan-Feb.
BACKGROUND/AIM: As D-dimer levels have been reported to reflect cancer activity, preoperative D-dimer levels may serve as a prognostic marker in patients with colorectal cancer. The aim of this study was to evaluate the prognostic significance of preoperative D-dimer levels in patients with stage I-III colorectal cancer who underwent curative surgery.
PATIENTS AND METHODS
A total of 264 patients who underwent curative surgery for stage I-III colorectal cancer between January 2015 and December 2019 were enrolled in this study.
RESULTS
The median preoperative D-dimer level was 0.8 μg/ml (range=0.4-42.5 μg/ml). Based on the results of a receiver operating characteristic curve analysis, we set 1.45 as the cut-off value and classified patients into the low (n=215) and high D-dimer (n=49) groups. The high D-dimer group had significantly lower relapse-free and overall survival in comparison to the low D-dimer group (p<0.0001, p<0.0001, respectively).
CONCLUSION
Preoperative D-dimer levels can serve as a prognostic marker for stage I-III colorectal cancer.
背景/目的：由于据报道D-二聚体水平可反映癌症活动情况，术前D-二聚体水平可能作为结直肠癌患者的预后标志物。本研究的目的是评估接受根治性手术的Ⅰ-Ⅲ期结直肠癌患者术前D-二聚体水平的预后意义。
患者与方法
本研究纳入了2015年1月至2019年12月期间接受Ⅰ-Ⅲ期结直肠癌根治性手术的264例患者。
结果
术前D-二聚体水平中位数为0.8μg/ml（范围=0.4 - 42.5μg/ml）。基于受试者工作特征曲线分析结果，我们将截断值设定为1.45，并将患者分为低D-二聚体组（n = 215）和高D-二聚体组（n = 49）。与低D-二聚体组相比，高D-二聚体组的无复发生存率和总生存率显著更低（分别为p < 0.0001，p < 0.0001）。
结论
术前D-二聚体水平可作为Ⅰ-Ⅲ期结直肠癌的预后标志物。
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