Shibutani Masatsune, Maeda Kiyoshi, Nagahara Hisashi, Iseki Yasuhito, Ikeya Tetsuro, Hirakawa Kosei
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
Oncol Lett. 2017 Feb;13(2):1000-1006. doi: 10.3892/ol.2016.5487. Epub 2016 Dec 12.
A correlation between the lymphocyte-to-monocyte ratio (LMR) and the survival of patients with hematological malignancies has been reported previously. However, there have been few studies investigating the prognostic significance of LMR in patients with solid tumors. The aim of the present study was to evaluate the prognostic significance of preoperative LMR in patients with colorectal cancer (CRC). A total of 189 patients undergoing potentially curative surgery for CRC were enrolled. The LMR was calculated from preoperative blood samples by dividing absolute lymphocyte count by absolute monocyte count. A cut-off value of 4.8 was set based on the receiver operating characteristic curve; 116 patients were classified as high-LMR, and 73 patients classified as low-LMR. The high-LMR group exhibited significantly better relapse-free survival (P=0.0018) and overall survival (P=0.0127) rates than the low-LMR group. According to the multivariate analysis of survival, preoperative LMR was identified as an independent prognostic factor for relapse-free survival (P=0.041) and overall survival (P=0.031). Therefore, preoperative LMR is a useful prognostic marker in patients with CRC.
此前已有报道称淋巴细胞与单核细胞比值（LMR）与血液系统恶性肿瘤患者的生存率之间存在相关性。然而，很少有研究探讨LMR在实体瘤患者中的预后意义。本研究的目的是评估术前LMR在结直肠癌（CRC）患者中的预后意义。共有189例接受CRC根治性手术的患者入组。LMR通过术前血样计算得出，即绝对淋巴细胞计数除以绝对单核细胞计数。根据受试者工作特征曲线设定临界值为4.8；116例患者被归类为高LMR组，73例患者被归类为低LMR组。高LMR组的无复发生存率（P=0.0018）和总生存率（P=0.0127）显著高于低LMR组。根据生存的多因素分析，术前LMR被确定为无复发生存（P=0.041）和总生存（P=0.031）的独立预后因素。因此，术前LMR是CRC患者有用的预后标志物。
