Groleau G, Barish R, Tso E, Whye D, Browne B
Division of Emergency Medicine, University of Maryland Hospital, Baltimore 21201.
Am J Emerg Med. 1987 Nov;5(6):527-32. doi: 10.1016/0735-6757(87)90178-1.
The clinical diagnosis of lithium intoxication can be elusive because of the slow onset and diversity of toxic manifestations. Mental status and neurologic symptoms often predominate. After the diagnosis is made, management depends on the clinical presentation and serum lithium level. Hemodialysis is the treatment of choice for severe lithium intoxication. Two cases of lithium intoxication are presented that demonstrate that predisposing factors and drug interactions play major roles. A review is given of the pathophysiology, presenting signs, symptoms, and approaches to treatment of lithium intoxication.
锂中毒的临床诊断可能难以捉摸，因为其中毒表现出现缓慢且具有多样性。精神状态和神经症状往往较为突出。确诊后，治疗方法取决于临床表现和血清锂水平。血液透析是重度锂中毒的首选治疗方法。本文介绍了两例锂中毒病例，表明诱发因素和药物相互作用起着主要作用。本文还综述了锂中毒的病理生理学、呈现的体征、症状及治疗方法。
