School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
Division of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, 57000 Kuala Lumpur, Malaysia.
Biol Chem. 2023 Jan 13;404(6):551-567. doi: 10.1515/hsz-2022-0228. Print 2023 May 25.
Increase evidence from epidemiological studies have shown an inverse association between Parkinson's disease (PD) and lung cancer. PD and lung cancer are both geriatric diseases, where these two diseases are sharing some common genetic determinants. Several PD-associated genes including alpha synuclein (SNCA), PTEN-induced kinase 1 (PINK1), parkin, parkinsonism associated deglycase (DJ-1), leucine-rich repeat kinase 2 (LRRK2), F-box protein 7 (FBXO7) and ubiquitin C-terminal hydrolase L1 (UCHL1) were reported to have altered expressions in lung cancer patients. This indicates that certain PD-associated genes might be important in conferring anticancer effects. This review aims to depict the physiological functions of these genes, and discuss the putative roles of these PD-associated genes in lung cancer. The understanding of the roles of these genes in the lung cancer progression might be important in the identification of new treatment targets for lung cancer. Gene therapy that aims to alter the expressions of these genes could be developed for future anticancer therapy. As a result, studying the roles of these genes in lung cancer may also help to understand their involvements as well as their roles in the pathogenesis of PD.
越来越多的流行病学研究证据表明，帕金森病（PD）与肺癌之间存在负相关关系。PD 和肺癌都是老年病，这两种疾病有一些共同的遗传决定因素。一些与 PD 相关的基因，包括α突触核蛋白（SNCA）、PTEN 诱导的激酶 1（PINK1）、parkin、帕金森病相关糖基化酶（DJ-1）、富含亮氨酸重复激酶 2（LRRK2）、F-box 蛋白 7（FBXO7）和泛素 C 末端水解酶 L1（UCHL1），据报道在肺癌患者中表达发生改变。这表明某些与 PD 相关的基因可能在赋予抗癌作用方面很重要。这篇综述旨在描述这些基因的生理功能，并讨论这些与 PD 相关的基因在肺癌中的潜在作用。了解这些基因在肺癌进展中的作用对于确定肺癌的新治疗靶点可能很重要。旨在改变这些基因表达的基因治疗可以为未来的抗癌治疗开发。因此，研究这些基因在肺癌中的作用也有助于了解它们在 PD 发病机制中的作用以及它们的作用。
