Crystal Growth and Nano-Science Research Center, Department of Physics, Government College (A), Rajamahendravaram, Andhra Pradesh 533105, India; Department of Physics, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India; Department of Physics, Dr VS Krishna Government Degree College (A), Visakhapatnam, A.P, India.
Crystal Growth and Nano-Science Research Center, Department of Physics, Government College (A), Rajamahendravaram, Andhra Pradesh 533105, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Apr 15;291:122297. doi: 10.1016/j.saa.2022.122297. Epub 2022 Dec 31.
Zinc oxide (ZnO) is one of the semiconductor materials with unique antimicrobial properties towards various microorganisms. In this article, pure and Na doped ZnO nanopowders were synthesized by easiest and cost-effective co-precipitation process. X-ray diffraction (XRD),Fourier transform infrared spectroscopy(FT-IR), ultraviolet - visible (UV - Vis) spectroscopy, scanning electron microscopy(SEM), and Energy dispersive X-ray analysis (EDAX) techniques were used to characterize the particle size, surface morphology and chemical composition of prepared materials. The XRD analysis revealed that the samples exhibiting hexagonal wurtzite crystal structure with high crystallinity and the average crystallite size values increased from 23.51 to 28.118 nm. The UV - Vis spectroscopy results exposed that the bandgap energy (E) of the samples with the values in the range of 3.068-3.301 eV. The SEM micrographs showed that the morphology of the of synthesized particles are hexagonal and spherical in nanometric size. The EDX spectra confirmed the elemental composition of Na, Zn and O in the crystal lattice and FTIR spectroscopic data proved the formation of functional groups and the presence of chemical bonding at the ZnO interface.Antibacterial activity of pure and Na doped Zinc oxide nanoparticles against Gram-negative pathogenssuch as Escherichia coli, Pseudomonas aeruginosa & Klebsiella pneumoniae and Gram-positive pathogens such as Staphylococcus aureus reveal that the zone of inhibition increases with increasing Na concentration. The antifungal activity against Aspergillus and Candida was investigated.These results demonstrated that the pure and Na doped ZnO samples exhibit enhanced antibacterial and antifungal activity with increasing particle sizein presence of visible light and they could be used as good antibacterial as well as antifungal agents.
氧化锌（ZnO）是一种具有独特抗菌性能的半导体材料，对各种微生物都有抗菌作用。本文采用最简单、最具成本效益的共沉淀法合成了纯氧化锌和掺钠氧化锌纳米粉末。采用 X 射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）、紫外-可见（UV-Vis）光谱、扫描电子显微镜（SEM）和能谱（EDAX）技术对制备材料的粒径、表面形貌和化学成分进行了表征。XRD 分析表明，样品具有六方纤锌矿晶体结构，结晶度高，平均晶粒尺寸从 23.51nm 增加到 28.118nm。UV-Vis 光谱结果表明，样品的带隙能（E）在 3.068-3.301eV 范围内。SEM 显微照片显示，合成粒子的形貌为纳米级的六方和球形。EDX 能谱证实了晶格中 Na、Zn 和 O 的元素组成，FTIR 光谱数据证明了功能基团的形成和 ZnO 界面处化学键的存在。纯氧化锌和掺钠氧化锌纳米粒子对革兰氏阴性病原体（如大肠杆菌、铜绿假单胞菌和肺炎克雷伯菌）和革兰氏阳性病原体（如金黄色葡萄球菌）的抗菌活性表明，随着 Na 浓度的增加，抑菌圈增大。还研究了纯氧化锌和掺钠氧化锌纳米粒子对曲霉属和念珠菌属的抗真菌活性。这些结果表明，在可见光存在下，纯氧化锌和掺钠 ZnO 样品的粒径增大，表现出增强的抗菌和抗真菌活性，可作为良好的抗菌和抗真菌剂。
