抗坏血酸补充剂对改善高尿酸血症对白化 Wistar 大鼠海马（结构和功能研究）的有害影响的潜力。

Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats' Hippocampus (Structural and Functional Study).

机构信息

Biomedical Sciences Department, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.

Anatomy and Embryology Department, College of Medicine, Tanta University, Tanta, Egypt.

出版信息

Neuroendocrinology. 2023;113(6):615-624. doi: 10.1159/000529061. Epub 2023 Jan 12.

DOI:10.1159/000529061

PMID:36634641

Abstract

INTRODUCTION

Diet rich in purines may increase the serum level of uric acid causing hyperuricemia, contributing to learning and memory to impairments. Ascorbic acid has a potent antioxidant potential. The hippocampus is a pivotal component of human brains and other vertebrates that plays crucial roles in the consolidation of information and spatial memory. Our study was mainly designated to examine the potential palliative role of ascorbic acid supplements on harmful effects induced hyperuricemia on the hippocampus of albino Wistar rats.

METHODS

Forty rats were subgrouped into the control group, ascorbate-only group, hyperuricemic group, and combined hyperuricemia and ascorbate group.

RESULTS

Ascorbic acid has strongly preserved the histological architecture and maintained the normal hippocampal functions in the hyperuricemic group.

CONCLUSION

The anti-inflammatory and antioxidant properties of ascorbic acid could protect the hippocampus of albino Wistar rats against the hazardous impact of hyperuricemia.

摘要

简介

富含嘌呤的饮食可能会增加血清尿酸水平，导致高尿酸血症，从而损害学习和记忆能力。抗坏血酸具有很强的抗氧化潜力。海马体是人类大脑和其他脊椎动物的关键组成部分，在信息整合和空间记忆中起着至关重要的作用。我们的研究主要旨在研究抗坏血酸补充剂对高尿酸血症对白化 Wistar 大鼠海马体的有害影响的潜在缓解作用。