采用准确的长读测序技术获取完整的基因组、转录组和表观基因组。
Approaching complete genomes, transcriptomes and epi-omes with accurate long-read sequencing.
机构信息
Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Department of Molecular Genetics, Ohio State University, Columbus, OH, USA.
出版信息
Nat Methods. 2023 Jan;20(1):12-16. doi: 10.1038/s41592-022-01716-8.
Abstract
The year 2022 will be remembered as the turning point for accurate long-read sequencing, which now establishes the gold standard for speed and accuracy at competitive costs. We discuss the key bioinformatics techniques needed to power long reads across application areas and close with our vision for long-read sequencing over the coming years.
摘要
2022 年将被铭记为准确长读测序的转折点，它现在以具有竞争力的成本确立了速度和准确性的黄金标准。我们讨论了在各个应用领域中为长读测序提供动力所需的关键生物信息学技术，并对未来几年的长读测序技术进行了展望。
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