Duff G R, Watt A H, Graham P A
Department of Ophthalmology, University Hospital of Wales.
Br J Ophthalmol. 1987 Sep;71(9):698-700. doi: 10.1136/bjo.71.9.698.
We compared the effects of oral nadolol 20 mg once daily and topical timolol 0.25% twice daily on the intraocular pressures of 22 glaucoma suspects, in a 12 week double-masked crossover study. Both nadolol and timolol reduced intraocular pressure (p less than 0.001). The reductions in intraocular pressure did not differ significantly after two weeks and four weeks of treatment. Nine of these subjects underwent treadmill exercise tests in order to compare the effects of nadolol and timolol on the cardiovascular system. The effects of the two treatments on blood pressure were comparable, but nadolol caused a significantly greater reduction in heart rate than timolol at rest (p less than 0.05). Nadolol reduces intraocular pressure effectively and may prove a useful alternative treatment for chronic simple glaucoma.
在一项为期12周的双盲交叉研究中，我们比较了每日一次口服20毫克纳多洛尔和每日两次局部使用0.25%噻吗洛尔对22名青光眼疑似患者眼压的影响。纳多洛尔和噻吗洛尔均能降低眼压（p<0.001）。治疗两周和四周后，眼压降低幅度无显著差异。其中9名受试者接受了跑步机运动测试，以比较纳多洛尔和噻吗洛尔对心血管系统的影响。两种治疗对血压的影响相当，但在静息状态下，纳多洛尔引起的心率降低幅度明显大于噻吗洛尔（p<0.05）。纳多洛尔能有效降低眼压，可能是慢性单纯性青光眼的一种有用替代治疗方法。
