Rennie I G, Smerdon D L
Am J Ophthalmol. 1985 Sep 15;100(3):445-7. doi: 10.1016/0002-9394(85)90511-2.
We compared the effects of once-daily oral administration of 20 mg and 40 mg of nadolol vs placebo in 40 normal volunteers in a randomized, double-masked trial. Each of 23 women and 17 men (ranging in age from 18 to 50 years) had intraocular pressure, pulse rate, blood pressure, pupil size, amplitude of accommodation, and near point measured immediately before treatment and then at 24 hours, day 8, and day 15 after treatment. Both dosages of nadolol produced significant decreases in intraocular pressure at three hours (P less than .001). Although both dosages decreased intraocular pressure at 24 hours compared with placebo, only the change with the 40-mg dose was significant (P less than .05). Although both dosages produced significant decreases in pulse rate and blood pressure, side effects were minimal.
在一项随机、双盲试验中，我们比较了40名正常志愿者每日口服一次20毫克和40毫克纳多洛尔与安慰剂的效果。23名女性和17名男性（年龄在18至50岁之间）在治疗前、治疗后24小时、第8天和第15天分别测量眼压、脉搏率、血压、瞳孔大小、调节幅度和近点。两种剂量的纳多洛尔在三小时时均使眼压显著降低（P<0.001）。虽然与安慰剂相比，两种剂量在24小时时均降低了眼压，但只有40毫克剂量的变化具有显著性（P<0.05）。虽然两种剂量均使脉搏率和血压显著降低，但副作用极小。
