Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia, Morocco. BP 509, Boutalamine, Errachidia, Morocco.
Cardiovasc Hematol Agents Med Chem. 2023;21(3):202-212. doi: 10.2174/1871525721666230111150501.
The aim of the study was to investigate the antihypertensive effect of L-Tartaric acid.
L-Tartaric acid (L-TA) is a well-known weak organic acid that naturally occurs in a wide range of fruits, most notably in grapes, tamarind, and citrus.
The present study aimed to assess the effect of acute and subchronic administration of L-TA on blood pressure parameters in normotensive and hypertensive rats as well as its vasorelaxant potency.
In the current study, the antihypertensive activity of L-TA was pharmacologically studied. L-NAME-induced hypertensive and normotensive rats received L-TA (80 and 240 mg/kg) orally over six hours for the acute experiment and seven days for the subchronic treatment. Thereafter, systolic, diastolic, mean, mid arterial blood pressure, and pulse pressure as well as heart rate were evaluated. In the in vitro experiment, the vasorelaxant ability of L-TA was performed in ratisolated thoracic aorta.
An important drop in blood pressure was recorded in L-NAME-induced hypertensives treated with L-TA. This molecule also produced a dose-dependent relaxation of the aorta precontracted with norepinephrine (NEP) and KCl. The study demonstrated that the vasorelaxant capacity of L-TA seems to be exerted through the activation of eNOS/NO/cGMP pathways.
本研究旨在探讨 L-酒石酸的降压作用。
L-酒石酸（L-TA）是一种众所周知的弱有机酸，广泛存在于各种水果中，尤以葡萄、罗望子和柑橘中含量丰富。
本研究旨在评估 L-TA 急性和亚慢性给药对正常血压和高血压大鼠血压参数的影响，以及其血管舒张活性。
在本研究中，我们对 L-TA 的降压活性进行了药理学研究。L-NAME 诱导的高血压和正常血压大鼠分别接受 L-TA（80 和 240mg/kg）口服治疗 6 小时（急性实验）和 7 天（亚慢性治疗）。然后评估收缩压、舒张压、平均压、中动脉压、脉压和心率。在离体实验中，我们在大鼠离体胸主动脉中评估了 L-TA 的血管舒张能力。
L-TA 治疗可使 L-NAME 诱导的高血压大鼠血压显著下降。该分子还可剂量依赖性地舒张预先用去甲肾上腺素（NEP）和 KCl 收缩的主动脉。研究表明，L-TA 的血管舒张作用似乎是通过激活 eNOS/NO/cGMP 途径来实现的。
