药物诱导的微生物组变化：孕期的考量因素
Drug-Induced Microbiome Changes: Considerations in Pregnancy.
作者信息
White Nicole D
机构信息
School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA (NDW).
出版信息
Am J Lifestyle Med. 2022 Oct 7;17(1):50-53. doi: 10.1177/15598276221130259. eCollection 2023 Jan-Feb.
Abstract
During pregnancy, the maternal microbiome is associated with both the health of the mother as well as the developing fetus. Several classes of drugs are known to influence the microbiome and their use in pregnancy may impact maternal/fetal outcomes and long-term health of offspring. The drug-microbiome interactions of antibiotics, proton pump inhibitors, laxatives, metformin, and probiotics will be described, along with considerations for use of these agents in pregnancy.
摘要
在怀孕期间，母体微生物群与母亲的健康以及发育中的胎儿都有关联。已知几类药物会影响微生物群，它们在孕期的使用可能会影响母婴结局以及后代的长期健康。本文将描述抗生素、质子泵抑制剂、泻药、二甲双胍和益生菌的药物-微生物群相互作用，以及这些药物在孕期使用时的注意事项。
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