Department of Otolaryngology- Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Columbus, OH 43210, United States.
Department of Otolaryngology- Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Columbus, OH 43210, United States.
Oral Oncol. 2023 Feb;137:106300. doi: 10.1016/j.oraloncology.2022.106300. Epub 2023 Jan 11.
Oral cavity cancer (OCC) is traditionally associated with smoking, but there is an increasing prevalence of the disease among non-smokers. This review investigates possible modifiable risk factors in the development of OCC in non-smokers (OCCNS).
PubMed, EMBASE, Web of Science, and Scopus were searched for publications prior to June 2021. Comparative studies investigating modifiable OCCNS risk factors were identified following PRISMA guidelines. Publication date, population size, and results were indexed. Study quality was assessed using MINORS (Methodological Index for Non-Randomized Studies). Factors examined by multiple studies were analyzed using random-effect meta-analysis framework.
Literature search resulted in 1,625 unique publications. 52 records met inclusion criterion, investigating alcohol (n = 22), chewing products (n = 18), diet (n = 7), dental health (n = 11), and medical comorbidities (n = 6).
This review demonstrates the paucity of large studies investigating OCCNS risk factors. Further investigation is warranted to help clinicians risk-stratify patients without traditional risk factors.
口腔癌（OCC）传统上与吸烟有关，但不吸烟者中该疾病的发病率正在上升。本综述调查了非吸烟者（OCCNS）中口腔癌发展的可能可改变的危险因素。
在 2021 年 6 月之前，在 PubMed、EMBASE、Web of Science 和 Scopus 上搜索出版物。根据 PRISMA 指南确定了调查可改变的 OCCNS 危险因素的比较研究。索引了出版日期、人口规模和结果。使用 MINORS（非随机研究方法学指数）评估研究质量。使用随机效应荟萃分析框架分析了多项研究检查的因素。
文献检索产生了 1625 条独特的出版物。52 条记录符合纳入标准，调查了酒精（n=22）、咀嚼产品（n=18）、饮食（n=7）、口腔健康（n=11）和医疗合并症（n=6）。
本综述表明，研究 OCCNS 危险因素的大型研究很少。需要进一步研究，以帮助临床医生对没有传统危险因素的患者进行风险分层。
