非吸烟者口腔癌的可改变风险因素：系统评价和荟萃分析。

Modifiable risk factors for oral cavity cancer in non-smokers: A systematic review and meta-analysis.

机构信息

Department of Otolaryngology- Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Columbus, OH 43210, United States.

出版信息

Oral Oncol. 2023 Feb;137:106300. doi: 10.1016/j.oraloncology.2022.106300. Epub 2023 Jan 11.

DOI:10.1016/j.oraloncology.2022.106300

PMID:36638697

Abstract

BACKGROUND

Oral cavity cancer (OCC) is traditionally associated with smoking, but there is an increasing prevalence of the disease among non-smokers. This review investigates possible modifiable risk factors in the development of OCC in non-smokers (OCCNS).

METHODS

PubMed, EMBASE, Web of Science, and Scopus were searched for publications prior to June 2021. Comparative studies investigating modifiable OCCNS risk factors were identified following PRISMA guidelines. Publication date, population size, and results were indexed. Study quality was assessed using MINORS (Methodological Index for Non-Randomized Studies). Factors examined by multiple studies were analyzed using random-effect meta-analysis framework.

RESULTS

Literature search resulted in 1,625 unique publications. 52 records met inclusion criterion, investigating alcohol (n = 22), chewing products (n = 18), diet (n = 7), dental health (n = 11), and medical comorbidities (n = 6).

CONCLUSION

This review demonstrates the paucity of large studies investigating OCCNS risk factors. Further investigation is warranted to help clinicians risk-stratify patients without traditional risk factors.

摘要

背景

口腔癌（OCC）传统上与吸烟有关，但不吸烟者中该疾病的发病率正在上升。本综述调查了非吸烟者（OCCNS）中口腔癌发展的可能可改变的危险因素。

方法

在 2021 年 6 月之前，在 PubMed、EMBASE、Web of Science 和 Scopus 上搜索出版物。根据 PRISMA 指南确定了调查可改变的 OCCNS 危险因素的比较研究。索引了出版日期、人口规模和结果。使用 MINORS（非随机研究方法学指数）评估研究质量。使用随机效应荟萃分析框架分析了多项研究检查的因素。